ZIC1.H14RSNP.2.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ZIC1.H14RSNP.2.S.B
Gene (human)	ZIC1 (GeneCards)
Gene synonyms (human)	ZIC, ZNF201
Gene (mouse)	Zic1
Gene synonyms (mouse)	Zic
LOGO
LOGO (reverse complement)
Motif subtype	2
Quality	B

Motif length	16
Consensus	dMdCMGCGGGGGGYvn
GC content	70.04%
Information content (bits; total / per base)	16.232 / 1.015
Data sources	HT-SELEX
Aligned words	5931
Previous names	ZIC1.H12RSNP.2.S.B

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	2 (14)	0.826	0.853	0.695	0.746	0.678	0.733	1.778	2.05	62.301	97.921

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.999	0.998	0.998	0.996	0.991	0.988
Overall, 6 experiments	best	1.0	0.999	0.999	0.999	0.998	0.997
Methyl HT-SELEX, 2 experiments	median	0.999	0.999	0.999	0.998	0.996	0.995
Methyl HT-SELEX, 2 experiments	best	1.0	0.999	0.999	0.999	0.998	0.997
Non-Methyl HT-SELEX, 4 experiments	median	0.926	0.93	0.831	0.845	0.782	0.797
Non-Methyl HT-SELEX, 4 experiments	best	0.999	0.998	0.998	0.997	0.996	0.994

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.934	0.407	0.917	0.559
batch 2	0.814	0.564	0.789	0.571

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	C2H2 zinc finger factors {2.3} (TFClass)
TF family	More than 3 adjacent zinc fingers {2.3.3} (TFClass)
TF subfamily	GLI-like {2.3.3.1} (TFClass)
TFClass ID	TFClass: 2.3.3.1.7
HGNC	HGNC:12872
MGI	MGI:106683
EntrezGene (human)	GeneID:7545 (SSTAR profile)
EntrezGene (mouse)	GeneID:22771 (SSTAR profile)
UniProt ID (human)	ZIC1_HUMAN
UniProt ID (mouse)	ZIC1_MOUSE
UniProt AC (human)	Q15915 (TFClass)
UniProt AC (mouse)	P46684 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 2 mouse
HT-SELEX	4
Methyl-HT-SELEX	2
Genomic HT-SELEX	0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq	0
PBM	0

PCM	ZIC1.H14RSNP.2.S.B.pcm
PWM	ZIC1.H14RSNP.2.S.B.pwm
PFM	ZIC1.H14RSNP.2.S.B.pfm
Threshold to P-value map	ZIC1.H14RSNP.2.S.B.thr
Motif in other formats
JASPAR format	ZIC1.H14RSNP.2.S.B_jaspar_format.txt
MEME format	ZIC1.H14RSNP.2.S.B_meme_format.meme
Transfac format	ZIC1.H14RSNP.2.S.B_transfac_format.txt
Homer format	ZIC1.H14RSNP.2.S.B_homer_format_0.001.txt ZIC1.H14RSNP.2.S.B_homer_format_0.0005.txt ZIC1.H14RSNP.2.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1267.75	332.75	2382.75	1947.75
02	835.5	4455.5	488.5	151.5
03	2816.0	333.0	1589.0	1193.0
04	67.0	5637.0	63.0	164.0
05	4460.0	902.0	292.0	277.0
06	1138.0	39.0	4743.0	11.0
07	13.0	5398.0	54.0	466.0
08	1889.0	1.0	4025.0	16.0
09	6.0	8.0	5823.0	94.0
10	17.0	74.0	5817.0	23.0
11	378.0	31.0	5048.0	474.0
12	159.0	106.0	5210.0	456.0
13	231.0	52.0	5240.0	408.0
14	144.0	1248.0	629.0	3910.0
15	1765.0	3018.0	705.0	443.0
16	1556.5	1432.5	1283.5	1658.5

PFM

	A	C	G	T
01	0.214	0.056	0.402	0.328
02	0.141	0.751	0.082	0.026
03	0.475	0.056	0.268	0.201
04	0.011	0.95	0.011	0.028
05	0.752	0.152	0.049	0.047
06	0.192	0.007	0.8	0.002
07	0.002	0.91	0.009	0.079
08	0.318	0.0	0.679	0.003
09	0.001	0.001	0.982	0.016
10	0.003	0.012	0.981	0.004
11	0.064	0.005	0.851	0.08
12	0.027	0.018	0.878	0.077
13	0.039	0.009	0.883	0.069
14	0.024	0.21	0.106	0.659
15	0.298	0.509	0.119	0.075
16	0.262	0.242	0.216	0.28

PWM

	A	C	G	T
01	-0.156	-1.489	0.474	0.272
02	-0.572	1.099	-1.107	-2.268
03	0.641	-1.488	0.069	-0.217
04	-3.067	1.334	-3.126	-2.19
05	1.1	-0.496	-1.619	-1.671
06	-0.264	-3.585	1.162	-4.725
07	-4.584	1.291	-3.275	-1.154
08	0.242	-6.149	0.998	-4.403
09	-5.202	-4.983	1.367	-2.737
10	-4.35	-2.97	1.366	-4.077
11	-1.362	-3.801	1.224	-1.137
12	-2.221	-2.619	1.256	-1.176
13	-1.851	-3.311	1.261	-1.287
14	-2.318	-0.172	-0.856	0.969
15	0.174	0.71	-0.742	-1.205
16	0.048	-0.034	-0.144	0.112

Standard thresholds

P-value	Threshold
0.001	2.14086
0.0005	3.43406
0.0001	6.12296