THB.H14RSNP.0.P.D motif - HOmo sapiens COmprehensive MOdel COllection

Motif	THB.H14RSNP.0.P.D
Gene (human)	THRB (GeneCards)
Gene synonyms (human)	ERBA2, NR1A2, THR1
Gene (mouse)	Thrb
Gene synonyms (mouse)	Erba2, Nr1a2
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	D

Motif length	17
Consensus	vRGKKYRnnYvAGGhSA
GC content	55.82%
Information content (bits; total / per base)	13.038 / 0.767
Data sources	ChIP-Seq
Aligned words	1000
Previous names	THB.H12RSNP.0.P.D

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.882	0.888	0.762	0.773	0.907	0.914	4.323	4.414	301.77	343.051
Mouse	1 (5)	0.709	0.763	0.661	0.744	0.675	0.742	2.62	3.156	79.215	120.509

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.861	0.818	0.79	0.746	0.714	0.684
Overall, 6 experiments	best	0.958	0.945	0.897	0.871	0.838	0.802
Methyl HT-SELEX, 2 experiments	median	0.921	0.895	0.855	0.821	0.783	0.752
Methyl HT-SELEX, 2 experiments	best	0.958	0.945	0.897	0.871	0.83	0.8
Non-Methyl HT-SELEX, 4 experiments	median	0.715	0.678	0.659	0.631	0.61	0.594
Non-Methyl HT-SELEX, 4 experiments	best	0.947	0.927	0.896	0.864	0.838	0.802

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	Nuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF family	Thyroid hormone receptor-related {2.1.2} (TFClass)
TF subfamily	T3R (NR1A) {2.1.2.2} (TFClass)
TFClass ID	TFClass: 2.1.2.2.2
HGNC	HGNC:11799
MGI	MGI:98743
EntrezGene (human)	GeneID:7068 (SSTAR profile)
EntrezGene (mouse)	GeneID:21834 (SSTAR profile)
UniProt ID (human)	THB_HUMAN
UniProt ID (mouse)	THB_MOUSE
UniProt AC (human)	P10828 (TFClass)
UniProt AC (mouse)	P37242 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 1 mouse
HT-SELEX	4
Methyl-HT-SELEX	2
Genomic HT-SELEX	0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq	0
PBM	0

PCM	THB.H14RSNP.0.P.D.pcm
PWM	THB.H14RSNP.0.P.D.pwm
PFM	THB.H14RSNP.0.P.D.pfm
Threshold to P-value map	THB.H14RSNP.0.P.D.thr
Motif in other formats
JASPAR format	THB.H14RSNP.0.P.D_jaspar_format.txt
MEME format	THB.H14RSNP.0.P.D_meme_format.meme
Transfac format	THB.H14RSNP.0.P.D_transfac_format.txt
Homer format	THB.H14RSNP.0.P.D_homer_format_0.001.txt THB.H14RSNP.0.P.D_homer_format_0.0005.txt THB.H14RSNP.0.P.D_homer_format_0.0001.txt

PCM

	A	C	G	T
01	295.0	150.0	436.0	119.0
02	521.0	15.0	450.0	14.0
03	68.0	12.0	859.0	61.0
04	117.0	10.0	729.0	144.0
05	16.0	122.0	170.0	692.0
06	49.0	704.0	119.0	128.0
07	796.0	43.0	102.0	59.0
08	162.0	310.0	227.0	301.0
09	175.0	384.0	181.0	260.0
10	33.0	298.0	84.0	585.0
11	242.0	209.0	490.0	59.0
12	763.0	11.0	216.0	10.0
13	5.0	1.0	976.0	18.0
14	4.0	6.0	934.0	56.0
15	283.0	175.0	85.0	457.0
16	66.0	765.0	95.0	74.0
17	823.0	44.0	77.0	56.0

PFM

	A	C	G	T
01	0.295	0.15	0.436	0.119
02	0.521	0.015	0.45	0.014
03	0.068	0.012	0.859	0.061
04	0.117	0.01	0.729	0.144
05	0.016	0.122	0.17	0.692
06	0.049	0.704	0.119	0.128
07	0.796	0.043	0.102	0.059
08	0.162	0.31	0.227	0.301
09	0.175	0.384	0.181	0.26
10	0.033	0.298	0.084	0.585
11	0.242	0.209	0.49	0.059
12	0.763	0.011	0.216	0.01
13	0.005	0.001	0.976	0.018
14	0.004	0.006	0.934	0.056
15	0.283	0.175	0.085	0.457
16	0.066	0.765	0.095	0.074
17	0.823	0.044	0.077	0.056

PWM

	A	C	G	T
01	0.164	-0.506	0.553	-0.735
02	0.731	-2.711	0.585	-2.773
03	-1.284	-2.909	1.229	-1.39
04	-0.752	-3.066	1.066	-0.547
05	-2.653	-0.71	-0.382	1.014
06	-1.602	1.031	-0.735	-0.663
07	1.153	-1.728	-0.887	-1.422
08	-0.43	0.214	-0.096	0.184
09	-0.354	0.427	-0.32	0.039
10	-1.981	0.175	-1.077	0.846
11	-0.032	-0.178	0.67	-1.422
12	1.111	-2.985	-0.145	-3.066
13	-3.622	-4.525	1.357	-2.546
14	-3.783	-3.484	1.313	-1.473
15	0.123	-0.354	-1.066	0.6
16	-1.313	1.114	-0.956	-1.201
17	1.187	-1.706	-1.162	-1.473

Standard thresholds

P-value	Threshold
0.001	3.92816
0.0005	4.91996
0.0001	6.98056