TFEB.H14CORE.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	TFEB.H14CORE.0.SM.B
Gene (human)	TFEB (GeneCards)
Gene synonyms (human)	BHLHE35
Gene (mouse)	Tfeb
Gene synonyms (mouse)	Tcfeb
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	12
Consensus	nnGTCACGTGMb
GC content	50.17%
Information content (bits; total / per base)	15.004 / 1.25
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	9975
Previous names	TFEB.H12CORE.0.SM.B

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.886	0.894	0.794	0.811	0.86	0.863	2.968	3.014	230.009	260.721

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.999	0.999	0.999	0.998	0.996	0.994
Overall, 6 experiments	best	1.0	1.0	1.0	0.999	0.999	0.999
Methyl HT-SELEX, 2 experiments	median	0.999	0.999	0.999	0.999	0.998	0.997
Methyl HT-SELEX, 2 experiments	best	1.0	0.999	1.0	0.999	0.999	0.999
Non-Methyl HT-SELEX, 4 experiments	median	0.999	0.999	0.999	0.998	0.978	0.977
Non-Methyl HT-SELEX, 4 experiments	best	1.0	1.0	0.999	0.999	0.998	0.997

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.797	0.532	0.831	0.655

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	bHLH-ZIP {1.2.6} (TFClass)
TF subfamily	TFE3 {1.2.6.1} (TFClass)
TFClass ID	TFClass: 1.2.6.1.2
HGNC	HGNC:11753
MGI	MGI:103270
EntrezGene (human)	GeneID:7942 (SSTAR profile)
EntrezGene (mouse)	GeneID:21425 (SSTAR profile)
UniProt ID (human)	TFEB_HUMAN
UniProt ID (mouse)	TFEB_MOUSE
UniProt AC (human)	P19484 (TFClass)
UniProt AC (mouse)	Q9R210 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 0 mouse
HT-SELEX	4
Methyl-HT-SELEX	2
Genomic HT-SELEX	0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq	0
PBM	0

PCM	TFEB.H14CORE.0.SM.B.pcm
PWM	TFEB.H14CORE.0.SM.B.pwm
PFM	TFEB.H14CORE.0.SM.B.pfm
Threshold to P-value map	TFEB.H14CORE.0.SM.B.thr
Motif in other formats
JASPAR format	TFEB.H14CORE.0.SM.B_jaspar_format.txt
MEME format	TFEB.H14CORE.0.SM.B_meme_format.meme
Transfac format	TFEB.H14CORE.0.SM.B_transfac_format.txt
Homer format	TFEB.H14CORE.0.SM.B_homer_format_0.001.txt TFEB.H14CORE.0.SM.B_homer_format_0.0005.txt TFEB.H14CORE.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	3268.5	1684.5	2261.5	2760.5
02	2803.0	2146.0	3324.0	1702.0
03	2567.0	34.0	7372.0	2.0
04	0.0	3.0	40.0	9932.0
05	0.0	9971.0	4.0	0.0
06	9973.0	1.0	0.0	1.0
07	0.0	9774.0	3.0	198.0
08	3121.0	64.0	6790.0	0.0
09	102.0	69.0	25.0	9779.0
10	10.0	8.0	9934.0	23.0
11	7261.75	982.75	824.75	905.75
12	418.5	3549.5	1192.5	4814.5

PFM

	A	C	G	T
01	0.328	0.169	0.227	0.277
02	0.281	0.215	0.333	0.171
03	0.257	0.003	0.739	0.0
04	0.0	0.0	0.004	0.996
05	0.0	1.0	0.0	0.0
06	1.0	0.0	0.0	0.0
07	0.0	0.98	0.0	0.02
08	0.313	0.006	0.681	0.0
09	0.01	0.007	0.003	0.98
10	0.001	0.001	0.996	0.002
11	0.728	0.099	0.083	0.091
12	0.042	0.356	0.12	0.483

PWM

	A	C	G	T
01	0.27	-0.392	-0.098	0.102
02	0.117	-0.15	0.287	-0.382
03	0.029	-4.231	1.083	-6.363
04	-6.989	-6.154	-4.078	1.381
05	-6.989	1.385	-5.982	-6.989
06	1.385	-6.628	-6.989	-6.628
07	-6.989	1.365	-6.154	-2.523
08	0.224	-3.628	1.001	-6.989
09	-3.175	-3.556	-4.516	1.366
10	-5.313	-5.49	1.381	-4.592
11	1.068	-0.93	-1.105	-1.011
12	-1.78	0.353	-0.737	0.657

Standard thresholds

P-value	Threshold
0.001	0.70468
0.0005	2.452515
0.0001	5.734795