TF7L1.H14RSNP.2.S.D motif - HOmo sapiens COmprehensive MOdel COllection

Motif	TF7L1.H14RSNP.2.S.D
Gene (human)	TCF7L1 (GeneCards)
Gene synonyms (human)	TCF3
Gene (mouse)	Tcf7l1
Gene synonyms (mouse)	Tcf3
LOGO
LOGO (reverse complement)
Motif subtype	2
Quality	D

Motif length	17
Consensus	nhYMGCGCCYCGATRWn
GC content	59.02%
Information content (bits; total / per base)	17.989 / 1.058
Data sources	HT-SELEX
Aligned words	3416
Previous names	TF7L1.H12RSNP.2.S.D

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.595	0.621	0.392	0.416	0.508	0.515	1.048	1.076	1.292	2.114
Mouse	1 (7)	0.58	0.59	0.39	0.395	0.486	0.488	0.951	0.966	0.161	0.432

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.957	0.953	0.82	0.824	0.683	0.707
Overall, 2 experiments	best	0.991	0.989	0.898	0.893	0.749	0.764
Methyl HT-SELEX, 1 experiments	median	0.922	0.918	0.742	0.755	0.617	0.65
Methyl HT-SELEX, 1 experiments	best	0.922	0.918	0.742	0.755	0.617	0.65
Non-Methyl HT-SELEX, 1 experiments	median	0.991	0.989	0.898	0.893	0.749	0.764
Non-Methyl HT-SELEX, 1 experiments	best	0.991	0.989	0.898	0.893	0.749	0.764

TF superclass	Other all-alpha-helical DNA-binding domains {4} (TFClass)
TF class	High-mobility group (HMG) domain factors {4.1} (TFClass)
TF family	TCF7-related {4.1.3} (TFClass)
TF subfamily	{4.1.3.0} (TFClass)
TFClass ID	TFClass: 4.1.3.0.2
HGNC	HGNC:11640
MGI	MGI:1202876
EntrezGene (human)	GeneID:83439 (SSTAR profile)
EntrezGene (mouse)	GeneID:21415 (SSTAR profile)
UniProt ID (human)	TF7L1_HUMAN
UniProt ID (mouse)	TF7L1_MOUSE
UniProt AC (human)	Q9HCS4 (TFClass)
UniProt AC (mouse)	Q9Z1J1 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 1 mouse
HT-SELEX	1
Methyl-HT-SELEX	1
Genomic HT-SELEX	0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq	0
PBM	0

PCM	TF7L1.H14RSNP.2.S.D.pcm
PWM	TF7L1.H14RSNP.2.S.D.pwm
PFM	TF7L1.H14RSNP.2.S.D.pfm
Threshold to P-value map	TF7L1.H14RSNP.2.S.D.thr
Motif in other formats
JASPAR format	TF7L1.H14RSNP.2.S.D_jaspar_format.txt
MEME format	TF7L1.H14RSNP.2.S.D_meme_format.meme
Transfac format	TF7L1.H14RSNP.2.S.D_transfac_format.txt
Homer format	TF7L1.H14RSNP.2.S.D_homer_format_0.001.txt TF7L1.H14RSNP.2.S.D_homer_format_0.0005.txt TF7L1.H14RSNP.2.S.D_homer_format_0.0001.txt

PCM

	A	C	G	T
01	943.75	827.75	640.75	1003.75
02	1154.0	397.0	356.0	1509.0
03	454.0	2239.0	179.0	544.0
04	2502.0	529.0	53.0	332.0
05	109.0	128.0	2959.0	220.0
06	19.0	3333.0	7.0	57.0
07	19.0	149.0	3230.0	18.0
08	13.0	2892.0	18.0	493.0
09	0.0	3162.0	2.0	252.0
10	16.0	1676.0	0.0	1724.0
11	0.0	3075.0	53.0	288.0
12	0.0	0.0	3416.0	0.0
13	3134.0	3.0	2.0	277.0
14	102.0	16.0	69.0	3229.0
15	508.0	173.0	2316.0	419.0
16	553.25	476.25	292.25	2094.25
17	822.0	812.0	794.0	988.0

PFM

	A	C	G	T
01	0.276	0.242	0.188	0.294
02	0.338	0.116	0.104	0.442
03	0.133	0.655	0.052	0.159
04	0.732	0.155	0.016	0.097
05	0.032	0.037	0.866	0.064
06	0.006	0.976	0.002	0.017
07	0.006	0.044	0.946	0.005
08	0.004	0.847	0.005	0.144
09	0.0	0.926	0.001	0.074
10	0.005	0.491	0.0	0.505
11	0.0	0.9	0.016	0.084
12	0.0	0.0	1.0	0.0
13	0.917	0.001	0.001	0.081
14	0.03	0.005	0.02	0.945
15	0.149	0.051	0.678	0.123
16	0.162	0.139	0.086	0.613
17	0.241	0.238	0.232	0.289

PWM

	A	C	G	T
01	0.1	-0.031	-0.287	0.161
02	0.3	-0.763	-0.872	0.568
03	-0.63	0.962	-1.554	-0.45
04	1.073	-0.477	-2.744	-0.941
05	-2.042	-1.885	1.241	-1.349
06	-3.706	1.36	-4.551	-2.674
07	-3.706	-1.735	1.329	-3.755
08	-4.042	1.218	-3.755	-0.548
09	-6.042	1.307	-5.358	-1.215
10	-3.86	0.673	-6.042	0.701
11	-6.042	1.279	-2.744	-1.082
12	-6.042	-6.042	1.385	-6.042
13	1.298	-5.136	-5.358	-1.121
14	-2.108	-3.86	-2.489	1.328
15	-0.518	-1.587	0.996	-0.71
16	-0.433	-0.582	-1.068	0.896
17	-0.038	-0.05	-0.073	0.145

Standard thresholds

P-value	Threshold
0.001	0.69401
0.0005	2.20056
0.0001	5.31261