TF7L1.H14INVIVO.2.S.C motif - HOmo sapiens COmprehensive MOdel COllection

Motif	TF7L1.H14INVIVO.2.S.C
Gene (human)	TCF7L1 (GeneCards)
Gene synonyms (human)	TCF3
Gene (mouse)	Tcf7l1
Gene synonyms (mouse)	Tcf3
LOGO
LOGO (reverse complement)
Motif subtype	2
Quality	C

Motif length	16
Consensus	dCAGCGCCYCGATGWn
GC content	59.91%
Information content (bits; total / per base)	21.103 / 1.319
Data sources	HT-SELEX
Aligned words	911
Previous names	TF7L1.H12INVIVO.2.S.C

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.616	0.638	0.434	0.465	0.526	0.53	1.109	1.12	0.699	2.658
Mouse	1 (7)	0.598	0.61	0.414	0.424	0.496	0.499	0.978	0.993	0	0.538

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.936	0.933	0.795	0.796	0.672	0.69
Overall, 2 experiments	best	0.982	0.979	0.863	0.858	0.728	0.739
Methyl HT-SELEX, 1 experiments	median	0.891	0.887	0.727	0.734	0.616	0.64
Methyl HT-SELEX, 1 experiments	best	0.891	0.887	0.727	0.734	0.616	0.64
Non-Methyl HT-SELEX, 1 experiments	median	0.982	0.979	0.863	0.858	0.728	0.739
Non-Methyl HT-SELEX, 1 experiments	best	0.982	0.979	0.863	0.858	0.728	0.739

TF superclass	Other all-alpha-helical DNA-binding domains {4} (TFClass)
TF class	High-mobility group (HMG) domain factors {4.1} (TFClass)
TF family	TCF7-related {4.1.3} (TFClass)
TF subfamily	{4.1.3.0} (TFClass)
TFClass ID	TFClass: 4.1.3.0.2
HGNC	HGNC:11640
MGI	MGI:1202876
EntrezGene (human)	GeneID:83439 (SSTAR profile)
EntrezGene (mouse)	GeneID:21415 (SSTAR profile)
UniProt ID (human)	TF7L1_HUMAN
UniProt ID (mouse)	TF7L1_MOUSE
UniProt AC (human)	Q9HCS4 (TFClass)
UniProt AC (mouse)	Q9Z1J1 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 1 mouse
HT-SELEX	1
Methyl-HT-SELEX	1
Genomic HT-SELEX	0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq	0
PBM	0

PCM	TF7L1.H14INVIVO.2.S.C.pcm
PWM	TF7L1.H14INVIVO.2.S.C.pwm
PFM	TF7L1.H14INVIVO.2.S.C.pfm
Threshold to P-value map	TF7L1.H14INVIVO.2.S.C.thr
Motif in other formats
JASPAR format	TF7L1.H14INVIVO.2.S.C_jaspar_format.txt
MEME format	TF7L1.H14INVIVO.2.S.C_meme_format.meme
Transfac format	TF7L1.H14INVIVO.2.S.C_transfac_format.txt
Homer format	TF7L1.H14INVIVO.2.S.C_homer_format_0.001.txt TF7L1.H14INVIVO.2.S.C_homer_format_0.0005.txt TF7L1.H14INVIVO.2.S.C_homer_format_0.0001.txt

PCM

	A	C	G	T
01	315.75	59.75	77.75	457.75
02	53.0	746.0	23.0	89.0
03	804.0	53.0	10.0	44.0
04	31.0	26.0	820.0	34.0
05	6.0	885.0	5.0	15.0
06	2.0	29.0	879.0	1.0
07	2.0	808.0	0.0	101.0
08	0.0	841.0	1.0	69.0
09	2.0	401.0	0.0	508.0
10	0.0	828.0	6.0	77.0
11	0.0	0.0	911.0	0.0
12	886.0	0.0	0.0	25.0
13	0.0	0.0	0.0	911.0
14	81.0	24.0	777.0	29.0
15	140.0	100.0	20.0	651.0
16	213.5	174.5	227.5	295.5

PFM

	A	C	G	T
01	0.347	0.066	0.085	0.502
02	0.058	0.819	0.025	0.098
03	0.883	0.058	0.011	0.048
04	0.034	0.029	0.9	0.037
05	0.007	0.971	0.005	0.016
06	0.002	0.032	0.965	0.001
07	0.002	0.887	0.0	0.111
08	0.0	0.923	0.001	0.076
09	0.002	0.44	0.0	0.558
10	0.0	0.909	0.007	0.085
11	0.0	0.0	1.0	0.0
12	0.973	0.0	0.0	0.027
13	0.0	0.0	0.0	1.0
14	0.089	0.026	0.853	0.032
15	0.154	0.11	0.022	0.715
16	0.234	0.192	0.25	0.324

PWM

	A	C	G	T
01	0.325	-1.317	-1.061	0.694
02	-1.434	1.181	-2.229	-0.928
03	1.256	-1.434	-2.976	-1.614
04	-1.948	-2.114	1.276	-1.86
05	-3.394	1.352	-3.533	-2.62
06	-4.126	-2.011	1.345	-4.441
07	-4.126	1.261	-4.903	-0.804
08	-4.903	1.301	-4.441	-1.177
09	-4.126	0.562	-4.903	0.798
10	-4.903	1.285	-3.394	-1.07
11	-4.903	-4.903	1.381	-4.903
12	1.353	-4.903	-4.903	-2.151
13	-4.903	-4.903	-4.903	1.381
14	-1.02	-2.189	1.222	-2.011
15	-0.482	-0.814	-2.358	1.045
16	-0.064	-0.264	-0.001	0.259

Standard thresholds

P-value	Threshold
0.001	-1.19154
0.0005	0.43271
0.0001	3.85381