TF7L1.H14INVITRO.2.S.C motif - HOmo sapiens COmprehensive MOdel COllection

Motif	TF7L1.H14INVITRO.2.S.C
Gene (human)	TCF7L1 (GeneCards)
Gene synonyms (human)	TCF3
Gene (mouse)	Tcf7l1
Gene synonyms (mouse)	Tcf3
LOGO
LOGO (reverse complement)
Motif subtype	2
Quality	C

Motif length	17
Consensus	nhYMGCGCCYCGATKhn
GC content	60.73%
Information content (bits; total / per base)	17.468 / 1.028
Data sources	HT-SELEX
Aligned words	6208
Previous names	TF7L1.H12INVITRO.2.S.C

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.549	0.567	0.358	0.37	0.468	0.502	1.016	1.14	0.244	0.959
Mouse	1 (7)	0.558	0.562	0.36	0.365	0.451	0.458	0.852	0.868	0	0.284

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.963	0.96	0.827	0.834	0.679	0.709
Overall, 2 experiments	best	0.993	0.992	0.914	0.909	0.746	0.769
Methyl HT-SELEX, 1 experiments	median	0.932	0.927	0.741	0.758	0.612	0.649
Methyl HT-SELEX, 1 experiments	best	0.932	0.927	0.741	0.758	0.612	0.649
Non-Methyl HT-SELEX, 1 experiments	median	0.993	0.992	0.914	0.909	0.746	0.769
Non-Methyl HT-SELEX, 1 experiments	best	0.993	0.992	0.914	0.909	0.746	0.769

TF superclass	Other all-alpha-helical DNA-binding domains {4} (TFClass)
TF class	High-mobility group (HMG) domain factors {4.1} (TFClass)
TF family	TCF7-related {4.1.3} (TFClass)
TF subfamily	{4.1.3.0} (TFClass)
TFClass ID	TFClass: 4.1.3.0.2
HGNC	HGNC:11640
MGI	MGI:1202876
EntrezGene (human)	GeneID:83439 (SSTAR profile)
EntrezGene (mouse)	GeneID:21415 (SSTAR profile)
UniProt ID (human)	TF7L1_HUMAN
UniProt ID (mouse)	TF7L1_MOUSE
UniProt AC (human)	Q9HCS4 (TFClass)
UniProt AC (mouse)	Q9Z1J1 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 1 mouse
HT-SELEX	1
Methyl-HT-SELEX	1
Genomic HT-SELEX	0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq	0
PBM	0

PCM	TF7L1.H14INVITRO.2.S.C.pcm
PWM	TF7L1.H14INVITRO.2.S.C.pwm
PFM	TF7L1.H14INVITRO.2.S.C.pfm
Threshold to P-value map	TF7L1.H14INVITRO.2.S.C.thr
Motif in other formats
JASPAR format	TF7L1.H14INVITRO.2.S.C_jaspar_format.txt
MEME format	TF7L1.H14INVITRO.2.S.C_meme_format.meme
Transfac format	TF7L1.H14INVITRO.2.S.C_transfac_format.txt
Homer format	TF7L1.H14INVITRO.2.S.C_homer_format_0.001.txt TF7L1.H14INVITRO.2.S.C_homer_format_0.0005.txt TF7L1.H14INVITRO.2.S.C_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1750.75	1490.75	1184.75	1781.75
02	2112.0	696.0	613.0	2787.0
03	837.0	4118.0	343.0	910.0
04	4407.0	924.0	216.0	661.0
05	142.0	231.0	5429.0	406.0
06	27.0	6130.0	20.0	31.0
07	8.0	238.0	5953.0	9.0
08	11.0	5211.0	22.0	964.0
09	2.0	6086.0	3.0	117.0
10	28.0	3488.0	5.0	2687.0
11	0.0	5881.0	184.0	143.0
12	2.0	11.0	6157.0	38.0
13	5238.0	58.0	73.0	839.0
14	512.0	200.0	263.0	5233.0
15	927.0	332.0	3929.0	1020.0
16	1019.25	942.25	732.25	3514.25
17	1494.0	1547.0	1378.0	1789.0

PFM

	A	C	G	T
01	0.282	0.24	0.191	0.287
02	0.34	0.112	0.099	0.449
03	0.135	0.663	0.055	0.147
04	0.71	0.149	0.035	0.106
05	0.023	0.037	0.875	0.065
06	0.004	0.987	0.003	0.005
07	0.001	0.038	0.959	0.001
08	0.002	0.839	0.004	0.155
09	0.0	0.98	0.0	0.019
10	0.005	0.562	0.001	0.433
11	0.0	0.947	0.03	0.023
12	0.0	0.002	0.992	0.006
13	0.844	0.009	0.012	0.135
14	0.082	0.032	0.042	0.843
15	0.149	0.053	0.633	0.164
16	0.164	0.152	0.118	0.566
17	0.241	0.249	0.222	0.288

PWM

	A	C	G	T
01	0.12	-0.04	-0.27	0.138
02	0.308	-0.8	-0.927	0.585
03	-0.616	0.975	-1.505	-0.533
04	1.043	-0.518	-1.963	-0.852
05	-2.378	-1.897	1.251	-1.337
06	-3.975	1.373	-4.249	-3.847
07	-5.028	-1.867	1.343	-4.934
08	-4.77	1.21	-4.163	-0.475
09	-5.918	1.365	-5.703	-2.568
10	-3.941	0.809	-5.377	0.548
11	-6.568	1.331	-2.122	-2.371
12	-5.918	-4.77	1.377	-3.655
13	1.215	-3.251	-3.029	-0.614
14	-1.106	-2.04	-1.768	1.214
15	-0.514	-1.537	0.928	-0.419
16	-0.42	-0.498	-0.75	0.816
17	-0.038	-0.003	-0.119	0.142

Standard thresholds

P-value	Threshold
0.001	1.03926
0.0005	2.49931
0.0001	5.53081