SPIB.H14INVIVO.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	SPIB.H14INVIVO.0.P.B
Gene (human)	SPIB (GeneCards)
Gene synonyms (human)
Gene (mouse)	Spib
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	17
Consensus	vRRWRRGGAAGTGRdRn
GC content	44.41%
Information content (bits; total / per base)	17.904 / 1.053
Data sources	ChIP-Seq
Aligned words	1001
Previous names	SPIB.H12INVIVO.0.P.B

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	4 (26)	0.987	0.992	0.971	0.981	0.99	0.993	6.674	7.226	652.803	878.137
Mouse	1 (5)	0.932	0.947	0.918	0.93	0.949	0.96	6.049	6.123	547.699	630.699

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 7 experiments	median	0.974	0.958	0.911	0.89	0.808	0.789
Overall, 7 experiments	best	0.998	0.998	0.991	0.989	0.962	0.955
Methyl HT-SELEX, 3 experiments	median	0.974	0.958	0.944	0.921	0.871	0.849
Methyl HT-SELEX, 3 experiments	best	0.998	0.998	0.991	0.989	0.962	0.955
Non-Methyl HT-SELEX, 4 experiments	median	0.968	0.952	0.903	0.883	0.764	0.768
Non-Methyl HT-SELEX, 4 experiments	best	0.994	0.99	0.983	0.976	0.954	0.941

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.889	0.472	0.851	0.573
batch 2	0.728	0.369	0.655	0.516

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	Ets-related {3.5.2} (TFClass)
TF subfamily	SPI-like {3.5.2.5} (TFClass)
TFClass ID	TFClass: 3.5.2.5.2
HGNC	HGNC:11242
MGI	MGI:892986
EntrezGene (human)	GeneID:6689 (SSTAR profile)
EntrezGene (mouse)	GeneID:272382 (SSTAR profile)
UniProt ID (human)	SPIB_HUMAN
UniProt ID (mouse)	SPIB_MOUSE
UniProt AC (human)	Q01892 (TFClass)
UniProt AC (mouse)	O35906 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	4 human, 1 mouse
HT-SELEX	4
Methyl-HT-SELEX	3
Genomic HT-SELEX	0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq	0
PBM	0

PCM	SPIB.H14INVIVO.0.P.B.pcm
PWM	SPIB.H14INVIVO.0.P.B.pwm
PFM	SPIB.H14INVIVO.0.P.B.pfm
Threshold to P-value map	SPIB.H14INVIVO.0.P.B.thr
Motif in other formats
JASPAR format	SPIB.H14INVIVO.0.P.B_jaspar_format.txt
MEME format	SPIB.H14INVIVO.0.P.B_meme_format.meme
Transfac format	SPIB.H14INVIVO.0.P.B_transfac_format.txt
Homer format	SPIB.H14INVIVO.0.P.B_homer_format_0.001.txt SPIB.H14INVIVO.0.P.B_homer_format_0.0005.txt SPIB.H14INVIVO.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	518.0	95.0	301.0	87.0
02	745.0	34.0	116.0	106.0
03	747.0	24.0	150.0	80.0
04	683.0	19.0	92.0	207.0
05	163.0	57.0	770.0	11.0
06	641.0	77.0	278.0	5.0
07	75.0	0.0	924.0	2.0
08	0.0	0.0	1000.0	1.0
09	1001.0	0.0	0.0	0.0
10	995.0	1.0	1.0	4.0
11	31.0	177.0	790.0	3.0
12	19.0	8.0	8.0	966.0
13	2.0	29.0	967.0	3.0
14	589.0	111.0	266.0	35.0
15	477.0	110.0	295.0	119.0
16	628.0	95.0	140.0	138.0
17	218.0	355.0	267.0	161.0

PFM

	A	C	G	T
01	0.517	0.095	0.301	0.087
02	0.744	0.034	0.116	0.106
03	0.746	0.024	0.15	0.08
04	0.682	0.019	0.092	0.207
05	0.163	0.057	0.769	0.011
06	0.64	0.077	0.278	0.005
07	0.075	0.0	0.923	0.002
08	0.0	0.0	0.999	0.001
09	1.0	0.0	0.0	0.0
10	0.994	0.001	0.001	0.004
11	0.031	0.177	0.789	0.003
12	0.019	0.008	0.008	0.965
13	0.002	0.029	0.966	0.003
14	0.588	0.111	0.266	0.035
15	0.477	0.11	0.295	0.119
16	0.627	0.095	0.14	0.138
17	0.218	0.355	0.267	0.161

PWM

	A	C	G	T
01	0.724	-0.957	0.183	-1.044
02	1.086	-1.953	-0.761	-0.85
03	1.089	-2.282	-0.507	-1.126
04	1.0	-2.498	-0.989	-0.188
05	-0.425	-1.456	1.119	-2.986
06	0.936	-1.163	0.104	-3.623
07	-1.189	-4.983	1.301	-4.214
08	-4.983	-4.983	1.38	-4.526
09	1.381	-4.983	-4.983	-4.983
10	1.375	-4.526	-4.526	-3.784
11	-2.041	-0.343	1.145	-3.976
12	-2.498	-3.254	-3.254	1.346
13	-4.214	-2.104	1.347	-3.976
14	0.852	-0.804	0.061	-1.926
15	0.642	-0.813	0.163	-0.736
16	0.916	-0.957	-0.575	-0.59
17	-0.137	0.348	0.064	-0.437

Standard thresholds

P-value	Threshold
0.001	1.02096
0.0005	2.47036
0.0001	5.48896