PO5F1.H14INVIVO.2.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	PO5F1.H14INVIVO.2.SM.B
Gene (human)	POU5F1 (GeneCards)
Gene synonyms (human)	OCT3, OCT4, OTF3
Gene (mouse)	Pou5f1
Gene synonyms (mouse)	Oct-3, Oct-4, Otf-3, Otf3
LOGO
LOGO (reverse complement)
Motif subtype	2
Quality	B

Motif length	17
Consensus	vdWTATGCTAATTAvbn
GC content	29.78%
Information content (bits; total / per base)	20.332 / 1.196
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	9630
Previous names	PO5F1.H12INVIVO.2.SM.B

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	27 (161)	0.729	0.842	0.6	0.74	0.759	0.883	2.513	3.418	53.004	123.387
Mouse	124 (789)	0.738	0.832	0.596	0.746	0.74	0.84	2.354	3.429	60.658	214.284

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	1.0	1.0	1.0	1.0	0.97	0.974
Overall, 2 experiments	best	1.0	1.0	1.0	1.0	1.0	1.0
Methyl HT-SELEX, 1 experiments	median	1.0	1.0	1.0	1.0	0.94	0.948
Methyl HT-SELEX, 1 experiments	best	1.0	1.0	1.0	1.0	0.94	0.948
Non-Methyl HT-SELEX, 1 experiments	median	1.0	1.0	1.0	1.0	1.0	1.0
Non-Methyl HT-SELEX, 1 experiments	best	1.0	1.0	1.0	1.0	1.0	1.0

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	POU {3.1.10} (TFClass)
TF subfamily	POU5 {3.1.10.5} (TFClass)
TFClass ID	TFClass: 3.1.10.5.1
HGNC	HGNC:9221
MGI	MGI:101893
EntrezGene (human)	GeneID:5460 (SSTAR profile)
EntrezGene (mouse)	GeneID:18999 (SSTAR profile)
UniProt ID (human)	PO5F1_HUMAN
UniProt ID (mouse)	PO5F1_MOUSE
UniProt AC (human)	Q01860 (TFClass)
UniProt AC (mouse)	P20263 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	27 human, 124 mouse
HT-SELEX	1
Methyl-HT-SELEX	1
Genomic HT-SELEX	0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq	0
PBM	0

PCM	PO5F1.H14INVIVO.2.SM.B.pcm
PWM	PO5F1.H14INVIVO.2.SM.B.pwm
PFM	PO5F1.H14INVIVO.2.SM.B.pfm
Threshold to P-value map	PO5F1.H14INVIVO.2.SM.B.thr
Motif in other formats
JASPAR format	PO5F1.H14INVIVO.2.SM.B_jaspar_format.txt
MEME format	PO5F1.H14INVIVO.2.SM.B_meme_format.meme
Transfac format	PO5F1.H14INVIVO.2.SM.B_transfac_format.txt
Homer format	PO5F1.H14INVIVO.2.SM.B_homer_format_0.001.txt PO5F1.H14INVIVO.2.SM.B_homer_format_0.0005.txt PO5F1.H14INVIVO.2.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	3639.0	2149.0	2509.0	1333.0
02	4812.5	1426.5	1835.5	1555.5
03	2370.0	92.0	805.0	6363.0
04	33.0	9.0	5.0	9583.0
05	9622.0	2.0	1.0	5.0
06	0.0	2.0	1.0	9627.0
07	0.0	1.0	9629.0	0.0
08	1.0	8665.0	0.0	964.0
09	2737.0	0.0	0.0	6893.0
10	9613.0	1.0	7.0	9.0
11	9627.0	1.0	1.0	1.0
12	4.0	1.0	3.0	9622.0
13	23.0	54.0	3211.0	6342.0
14	8012.0	185.0	633.0	800.0
15	3592.0	1264.0	4326.0	448.0
16	770.0	2759.0	4009.0	2092.0
17	1433.25	2902.25	2263.25	3031.25

PFM

	A	C	G	T
01	0.378	0.223	0.261	0.138
02	0.5	0.148	0.191	0.162
03	0.246	0.01	0.084	0.661
04	0.003	0.001	0.001	0.995
05	0.999	0.0	0.0	0.001
06	0.0	0.0	0.0	1.0
07	0.0	0.0	1.0	0.0
08	0.0	0.9	0.0	0.1
09	0.284	0.0	0.0	0.716
10	0.998	0.0	0.001	0.001
11	1.0	0.0	0.0	0.0
12	0.0	0.0	0.0	0.999
13	0.002	0.006	0.333	0.659
14	0.832	0.019	0.066	0.083
15	0.373	0.131	0.449	0.047
16	0.08	0.287	0.416	0.217
17	0.149	0.301	0.235	0.315

PWM

	A	C	G	T
01	0.413	-0.113	0.041	-0.59
02	0.692	-0.523	-0.271	-0.436
03	-0.016	-3.241	-1.094	0.971
04	-4.224	-5.363	-5.8	1.381
05	1.385	-6.33	-6.595	-5.8
06	-6.957	-6.33	-6.595	1.385
07	-6.957	-6.595	1.385	-6.957
08	-6.595	1.28	-6.957	-0.914
09	0.128	-6.957	-6.957	1.051
10	1.384	-6.595	-5.558	-5.363
11	1.385	-6.595	-6.595	-6.595
12	-5.948	-6.595	-6.121	1.385
13	-4.557	-3.757	0.288	0.968
14	1.202	-2.555	-1.333	-1.1
15	0.4	-0.643	0.586	-1.677
16	-1.138	0.136	0.51	-0.14
17	-0.518	0.187	-0.062	0.23

Standard thresholds

P-value	Threshold
0.001	-5.51194
0.0005	-3.39189
0.0001	1.40696