PO2F2.H14RSNP.1.M.D motif - HOmo sapiens COmprehensive MOdel COllection

Motif	PO2F2.H14RSNP.1.M.D
Gene (human)	POU2F2 (GeneCards)
Gene synonyms (human)	OCT2, OTF2
Gene (mouse)	Pou2f2
Gene synonyms (mouse)	Oct2, Otf2
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	D

Motif length	15
Consensus	hRMATATGCGMAWdn
GC content	36.93%
Information content (bits; total / per base)	15.863 / 1.058
Data sources	Methyl-HT-SELEX
Aligned words	2277
Previous names	PO2F2.H12RSNP.1.M.D

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	6 (39)	0.744	0.871	0.626	0.771	0.719	0.86	2.431	3.606	125.658	248.18

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 7 experiments	median	0.967	0.951	0.842	0.836	0.685	0.709
Overall, 7 experiments	best	0.989	0.98	0.973	0.961	0.939	0.913
Methyl HT-SELEX, 2 experiments	median	0.931	0.917	0.841	0.834	0.776	0.774
Methyl HT-SELEX, 2 experiments	best	0.977	0.959	0.965	0.944	0.939	0.913
Non-Methyl HT-SELEX, 5 experiments	median	0.967	0.951	0.842	0.836	0.685	0.709
Non-Methyl HT-SELEX, 5 experiments	best	0.989	0.98	0.973	0.961	0.887	0.88

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	POU {3.1.10} (TFClass)
TF subfamily	POU2 {3.1.10.2} (TFClass)
TFClass ID	TFClass: 3.1.10.2.2
HGNC	HGNC:9213
MGI	MGI:101897
EntrezGene (human)	GeneID:5452 (SSTAR profile)
EntrezGene (mouse)	GeneID:18987 (SSTAR profile)
UniProt ID (human)	PO2F2_HUMAN
UniProt ID (mouse)	PO2F2_MOUSE
UniProt AC (human)	P09086 (TFClass)
UniProt AC (mouse)	Q00196 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	6 human, 0 mouse
HT-SELEX	5
Methyl-HT-SELEX	2
Genomic HT-SELEX	0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq	0
PBM	0

PCM	PO2F2.H14RSNP.1.M.D.pcm
PWM	PO2F2.H14RSNP.1.M.D.pwm
PFM	PO2F2.H14RSNP.1.M.D.pfm
Threshold to P-value map	PO2F2.H14RSNP.1.M.D.thr
Motif in other formats
JASPAR format	PO2F2.H14RSNP.1.M.D_jaspar_format.txt
MEME format	PO2F2.H14RSNP.1.M.D_meme_format.meme
Transfac format	PO2F2.H14RSNP.1.M.D_transfac_format.txt
Homer format	PO2F2.H14RSNP.1.M.D_homer_format_0.001.txt PO2F2.H14RSNP.1.M.D_homer_format_0.0005.txt PO2F2.H14RSNP.1.M.D_homer_format_0.0001.txt

PCM

	A	C	G	T
01	474.5	657.5	238.5	906.5
02	515.25	89.25	1402.25	270.25
03	1386.0	615.0	87.0	189.0
04	1854.0	11.0	45.0	367.0
05	2.0	5.0	0.0	2270.0
06	2277.0	0.0	0.0	0.0
07	1.0	8.0	0.0	2268.0
08	0.0	0.0	1956.0	321.0
09	1.0	2269.0	0.0	7.0
10	394.0	0.0	1847.0	36.0
11	529.0	1372.0	50.0	326.0
12	1874.0	50.0	258.0	95.0
13	281.0	170.0	112.0	1714.0
14	1286.0	199.0	352.0	440.0
15	705.25	498.25	321.25	752.25

PFM

	A	C	G	T
01	0.208	0.289	0.105	0.398
02	0.226	0.039	0.616	0.119
03	0.609	0.27	0.038	0.083
04	0.814	0.005	0.02	0.161
05	0.001	0.002	0.0	0.997
06	1.0	0.0	0.0	0.0
07	0.0	0.004	0.0	0.996
08	0.0	0.0	0.859	0.141
09	0.0	0.996	0.0	0.003
10	0.173	0.0	0.811	0.016
11	0.232	0.603	0.022	0.143
12	0.823	0.022	0.113	0.042
13	0.123	0.075	0.049	0.753
14	0.565	0.087	0.155	0.193
15	0.31	0.219	0.141	0.33

PWM

	A	C	G	T
01	-0.181	0.144	-0.865	0.464
02	-0.099	-1.835	0.9	-0.741
03	0.888	0.077	-1.86	-1.096
04	1.178	-3.788	-2.499	-0.437
05	-4.978	-4.411	-5.689	1.381
06	1.384	-5.689	-5.689	-5.689
07	-5.272	-4.052	-5.689	1.38
08	-5.689	-5.689	1.232	-0.57
09	-5.272	1.38	-5.689	-4.158
10	-0.366	-5.689	1.175	-2.712
11	-0.073	0.878	-2.398	-0.555
12	1.189	-2.398	-0.787	-1.774
13	-0.703	-1.201	-1.612	1.1
14	0.813	-1.045	-0.479	-0.257
15	0.214	-0.133	-0.569	0.278

Standard thresholds

P-value	Threshold
0.001	1.54426
0.0005	3.05451
0.0001	6.18831