| Motif | PAX8.H14INVIVO.0.PSM.A |
| Gene (human) | PAX8 (GeneCards) |
| Gene synonyms (human) | |
| Gene (mouse) | Pax8 |
| Gene synonyms (mouse) | Pax-8 |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 0 |
| Quality | A |
| Motif | PAX8.H14INVIVO.0.PSM.A |
| Gene (human) | PAX8 (GeneCards) |
| Gene synonyms (human) | |
| Gene (mouse) | Pax8 |
| Gene synonyms (mouse) | Pax-8 |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 0 |
| Quality | A |
| Motif length | 21 |
| Consensus | bnddRhbYAnbbRWGYRKGWM |
| GC content | 50.36% |
| Information content (bits; total / per base) | 12.281 / 0.585 |
| Data sources | ChIP-Seq + HT-SELEX + Methyl-HT-SELEX |
| Aligned words | 144 |
| Previous names | PAX8.H12INVIVO.0.PSM.A |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Human | 1 (4) | 0.754 | 0.877 | 0.687 | 0.837 | 0.754 | 0.885 | 3.477 | 4.85 | 35.294 | 36.523 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 2 experiments | median | 0.993 | 0.991 | 0.957 | 0.951 | 0.885 | 0.885 |
| best | 1.0 | 1.0 | 0.999 | 0.998 | 0.986 | 0.984 | |
| Methyl HT-SELEX, 1 experiments | median | 0.986 | 0.982 | 0.915 | 0.904 | 0.783 | 0.787 |
| best | 0.986 | 0.982 | 0.915 | 0.904 | 0.783 | 0.787 | |
| Non-Methyl HT-SELEX, 1 experiments | median | 1.0 | 1.0 | 0.999 | 0.998 | 0.986 | 0.984 |
| best | 1.0 | 1.0 | 0.999 | 0.998 | 0.986 | 0.984 | |
| rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
|---|---|---|---|---|
| batch 1 | 0.585 | 0.172 | 0.54 | 0.332 |
| TF superclass | Helix-turn-helix domains {3} (TFClass) |
| TF class | Paired box factors {3.2} (TFClass) |
| TF family | PD {3.2.2} (TFClass) |
| TF subfamily | PAX2-like {3.2.2.2} (TFClass) |
| TFClass ID | TFClass: 3.2.2.2.3 |
| HGNC | HGNC:8622 |
| MGI | MGI:97492 |
| EntrezGene (human) | GeneID:7849 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:18510 (SSTAR profile) |
| UniProt ID (human) | PAX8_HUMAN |
| UniProt ID (mouse) | PAX8_MOUSE |
| UniProt AC (human) | Q06710 (TFClass) |
| UniProt AC (mouse) | Q00288 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 1 human, 0 mouse |
| HT-SELEX | 1 |
| Methyl-HT-SELEX | 1 |
| Genomic HT-SELEX | 0 overall: 0 Lysate, 0 IVT, 0 GFPIVT |
| SMiLE-Seq | 0 |
| PBM | 0 |
| PCM | PAX8.H14INVIVO.0.PSM.A.pcm |
| PWM | PAX8.H14INVIVO.0.PSM.A.pwm |
| PFM | PAX8.H14INVIVO.0.PSM.A.pfm |
| Threshold to P-value map | PAX8.H14INVIVO.0.PSM.A.thr |
| Motif in other formats | |
| JASPAR format | PAX8.H14INVIVO.0.PSM.A_jaspar_format.txt |
| MEME format | PAX8.H14INVIVO.0.PSM.A_meme_format.meme |
| Transfac format | PAX8.H14INVIVO.0.PSM.A_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 22.0 | 37.0 | 61.0 | 24.0 |
| 02 | 25.0 | 25.0 | 28.0 | 66.0 |
| 03 | 37.0 | 16.0 | 72.0 | 19.0 |
| 04 | 31.0 | 10.0 | 26.0 | 77.0 |
| 05 | 40.0 | 4.0 | 93.0 | 7.0 |
| 06 | 28.0 | 27.0 | 22.0 | 67.0 |
| 07 | 10.0 | 19.0 | 72.0 | 43.0 |
| 08 | 14.0 | 107.0 | 4.0 | 19.0 |
| 09 | 133.0 | 0.0 | 1.0 | 10.0 |
| 10 | 31.0 | 32.0 | 45.0 | 36.0 |
| 11 | 13.0 | 18.0 | 34.0 | 79.0 |
| 12 | 14.0 | 52.0 | 51.0 | 27.0 |
| 13 | 87.0 | 2.0 | 52.0 | 3.0 |
| 14 | 62.0 | 2.0 | 14.0 | 66.0 |
| 15 | 0.0 | 27.0 | 113.0 | 4.0 |
| 16 | 7.0 | 89.0 | 2.0 | 46.0 |
| 17 | 50.0 | 0.0 | 91.0 | 3.0 |
| 18 | 7.0 | 11.0 | 18.0 | 108.0 |
| 19 | 27.0 | 0.0 | 116.0 | 1.0 |
| 20 | 87.0 | 18.0 | 4.0 | 35.0 |
| 21 | 32.0 | 84.0 | 24.0 | 4.0 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.153 | 0.257 | 0.424 | 0.167 |
| 02 | 0.174 | 0.174 | 0.194 | 0.458 |
| 03 | 0.257 | 0.111 | 0.5 | 0.132 |
| 04 | 0.215 | 0.069 | 0.181 | 0.535 |
| 05 | 0.278 | 0.028 | 0.646 | 0.049 |
| 06 | 0.194 | 0.188 | 0.153 | 0.465 |
| 07 | 0.069 | 0.132 | 0.5 | 0.299 |
| 08 | 0.097 | 0.743 | 0.028 | 0.132 |
| 09 | 0.924 | 0.0 | 0.007 | 0.069 |
| 10 | 0.215 | 0.222 | 0.313 | 0.25 |
| 11 | 0.09 | 0.125 | 0.236 | 0.549 |
| 12 | 0.097 | 0.361 | 0.354 | 0.188 |
| 13 | 0.604 | 0.014 | 0.361 | 0.021 |
| 14 | 0.431 | 0.014 | 0.097 | 0.458 |
| 15 | 0.0 | 0.188 | 0.785 | 0.028 |
| 16 | 0.049 | 0.618 | 0.014 | 0.319 |
| 17 | 0.347 | 0.0 | 0.632 | 0.021 |
| 18 | 0.049 | 0.076 | 0.125 | 0.75 |
| 19 | 0.188 | 0.0 | 0.806 | 0.007 |
| 20 | 0.604 | 0.125 | 0.028 | 0.243 |
| 21 | 0.222 | 0.583 | 0.167 | 0.028 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | -0.471 | 0.026 | 0.514 | -0.389 |
| 02 | -0.35 | -0.35 | -0.242 | 0.591 |
| 03 | 0.026 | -0.77 | 0.676 | -0.61 |
| 04 | -0.144 | -1.198 | -0.313 | 0.742 |
| 05 | 0.102 | -1.961 | 0.928 | -1.508 |
| 06 | -0.242 | -0.277 | -0.471 | 0.606 |
| 07 | -1.198 | -0.61 | 0.676 | 0.172 |
| 08 | -0.893 | 1.067 | -1.961 | -0.61 |
| 09 | 1.282 | -3.4 | -2.81 | -1.198 |
| 10 | -0.144 | -0.114 | 0.216 | 0.0 |
| 11 | -0.961 | -0.66 | -0.055 | 0.768 |
| 12 | -0.893 | 0.357 | 0.338 | -0.277 |
| 13 | 0.863 | -2.441 | 0.357 | -2.172 |
| 14 | 0.53 | -2.441 | -0.893 | 0.591 |
| 15 | -3.4 | -0.277 | 1.121 | -1.961 |
| 16 | -1.508 | 0.885 | -2.441 | 0.238 |
| 17 | 0.319 | -3.4 | 0.907 | -2.172 |
| 18 | -1.508 | -1.113 | -0.66 | 1.076 |
| 19 | -0.277 | -3.4 | 1.147 | -2.81 |
| 20 | 0.863 | -0.66 | -1.961 | -0.027 |
| 21 | -0.114 | 0.828 | -0.389 | -1.961 |
| P-value | Threshold |
|---|---|
| 0.001 | 4.41196 |
| 0.0005 | 5.29541 |
| 0.0001 | 7.12681 |