| Motif | PAX8.H14CORE.0.PSM.A |
| Gene (human) | PAX8 (GeneCards) |
| Gene synonyms (human) | |
| Gene (mouse) | Pax8 |
| Gene synonyms (mouse) | Pax-8 |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 0 |
| Quality | A |
| Motif | PAX8.H14CORE.0.PSM.A |
| Gene (human) | PAX8 (GeneCards) |
| Gene synonyms (human) | |
| Gene (mouse) | Pax8 |
| Gene synonyms (mouse) | Pax-8 |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 0 |
| Quality | A |
| Motif length | 20 |
| Consensus | nRnbYRnTSAWGCGTGACSv |
| GC content | 57.53% |
| Information content (bits; total / per base) | 19.443 / 0.972 |
| Data sources | ChIP-Seq + HT-SELEX + Methyl-HT-SELEX |
| Aligned words | 9102 |
| Previous names | PAX8.H12CORE.0.PSM.A |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Human | 1 (4) | 0.692 | 0.791 | 0.627 | 0.754 | 0.656 | 0.772 | 2.873 | 3.963 | 46.219 | 59.569 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 2 experiments | median | 0.999 | 0.999 | 0.988 | 0.987 | 0.921 | 0.926 |
| best | 1.0 | 1.0 | 1.0 | 1.0 | 0.999 | 0.999 | |
| Methyl HT-SELEX, 1 experiments | median | 0.999 | 0.998 | 0.977 | 0.974 | 0.843 | 0.853 |
| best | 0.999 | 0.998 | 0.977 | 0.974 | 0.843 | 0.853 | |
| Non-Methyl HT-SELEX, 1 experiments | median | 1.0 | 1.0 | 1.0 | 1.0 | 0.999 | 0.999 |
| best | 1.0 | 1.0 | 1.0 | 1.0 | 0.999 | 0.999 | |
| rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
|---|---|---|---|---|
| batch 1 | 0.711 | 0.446 | 0.719 | 0.466 |
| TF superclass | Helix-turn-helix domains {3} (TFClass) |
| TF class | Paired box factors {3.2} (TFClass) |
| TF family | PD {3.2.2} (TFClass) |
| TF subfamily | PAX2-like {3.2.2.2} (TFClass) |
| TFClass ID | TFClass: 3.2.2.2.3 |
| HGNC | HGNC:8622 |
| MGI | MGI:97492 |
| EntrezGene (human) | GeneID:7849 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:18510 (SSTAR profile) |
| UniProt ID (human) | PAX8_HUMAN |
| UniProt ID (mouse) | PAX8_MOUSE |
| UniProt AC (human) | Q06710 (TFClass) |
| UniProt AC (mouse) | Q00288 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 1 human, 0 mouse |
| HT-SELEX | 1 |
| Methyl-HT-SELEX | 1 |
| Genomic HT-SELEX | 0 overall: 0 Lysate, 0 IVT, 0 GFPIVT |
| SMiLE-Seq | 0 |
| PBM | 0 |
| PCM | PAX8.H14CORE.0.PSM.A.pcm |
| PWM | PAX8.H14CORE.0.PSM.A.pwm |
| PFM | PAX8.H14CORE.0.PSM.A.pfm |
| Threshold to P-value map | PAX8.H14CORE.0.PSM.A.thr |
| Motif in other formats | |
| JASPAR format | PAX8.H14CORE.0.PSM.A_jaspar_format.txt |
| MEME format | PAX8.H14CORE.0.PSM.A_meme_format.meme |
| Transfac format | PAX8.H14CORE.0.PSM.A_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 1908.75 | 1506.75 | 2568.75 | 3117.75 |
| 02 | 3034.25 | 704.25 | 5014.25 | 349.25 |
| 03 | 2326.0 | 2080.0 | 2502.0 | 2194.0 |
| 04 | 53.0 | 2453.0 | 3240.0 | 3356.0 |
| 05 | 373.0 | 6365.0 | 112.0 | 2252.0 |
| 06 | 6609.0 | 352.0 | 1932.0 | 209.0 |
| 07 | 1815.0 | 2392.0 | 3324.0 | 1571.0 |
| 08 | 20.0 | 1785.0 | 75.0 | 7222.0 |
| 09 | 275.0 | 5530.0 | 3246.0 | 51.0 |
| 10 | 7672.0 | 10.0 | 1377.0 | 43.0 |
| 11 | 5830.0 | 255.0 | 123.0 | 2894.0 |
| 12 | 0.0 | 896.0 | 8204.0 | 2.0 |
| 13 | 4.0 | 9091.0 | 3.0 | 4.0 |
| 14 | 352.0 | 4.0 | 8735.0 | 11.0 |
| 15 | 15.0 | 12.0 | 242.0 | 8833.0 |
| 16 | 958.0 | 51.0 | 8042.0 | 51.0 |
| 17 | 8595.0 | 54.0 | 303.0 | 150.0 |
| 18 | 406.0 | 8573.0 | 56.0 | 67.0 |
| 19 | 428.0 | 2293.0 | 5786.0 | 595.0 |
| 20 | 2493.0 | 1769.0 | 3670.0 | 1170.0 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.21 | 0.166 | 0.282 | 0.343 |
| 02 | 0.333 | 0.077 | 0.551 | 0.038 |
| 03 | 0.256 | 0.229 | 0.275 | 0.241 |
| 04 | 0.006 | 0.27 | 0.356 | 0.369 |
| 05 | 0.041 | 0.699 | 0.012 | 0.247 |
| 06 | 0.726 | 0.039 | 0.212 | 0.023 |
| 07 | 0.199 | 0.263 | 0.365 | 0.173 |
| 08 | 0.002 | 0.196 | 0.008 | 0.793 |
| 09 | 0.03 | 0.608 | 0.357 | 0.006 |
| 10 | 0.843 | 0.001 | 0.151 | 0.005 |
| 11 | 0.641 | 0.028 | 0.014 | 0.318 |
| 12 | 0.0 | 0.098 | 0.901 | 0.0 |
| 13 | 0.0 | 0.999 | 0.0 | 0.0 |
| 14 | 0.039 | 0.0 | 0.96 | 0.001 |
| 15 | 0.002 | 0.001 | 0.027 | 0.97 |
| 16 | 0.105 | 0.006 | 0.884 | 0.006 |
| 17 | 0.944 | 0.006 | 0.033 | 0.016 |
| 18 | 0.045 | 0.942 | 0.006 | 0.007 |
| 19 | 0.047 | 0.252 | 0.636 | 0.065 |
| 20 | 0.274 | 0.194 | 0.403 | 0.129 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | -0.176 | -0.412 | 0.121 | 0.315 |
| 02 | 0.288 | -1.171 | 0.79 | -1.869 |
| 03 | 0.022 | -0.09 | 0.095 | -0.036 |
| 04 | -3.719 | 0.075 | 0.353 | 0.388 |
| 05 | -1.803 | 1.028 | -2.992 | -0.01 |
| 06 | 1.066 | -1.861 | -0.163 | -2.378 |
| 07 | -0.226 | 0.05 | 0.379 | -0.37 |
| 08 | -4.627 | -0.243 | -3.384 | 1.154 |
| 09 | -2.106 | 0.887 | 0.355 | -3.755 |
| 10 | 1.215 | -5.223 | -0.502 | -3.918 |
| 11 | 0.94 | -2.181 | -2.9 | 0.24 |
| 12 | -6.907 | -0.93 | 1.282 | -6.277 |
| 13 | -5.894 | 1.384 | -6.067 | -5.894 |
| 14 | -1.861 | -5.894 | 1.344 | -5.145 |
| 15 | -4.881 | -5.072 | -2.233 | 1.356 |
| 16 | -0.864 | -3.755 | 1.262 | -3.755 |
| 17 | 1.328 | -3.701 | -2.01 | -2.705 |
| 18 | -1.719 | 1.326 | -3.666 | -3.493 |
| 19 | -1.667 | 0.008 | 0.933 | -1.339 |
| 20 | 0.091 | -0.251 | 0.478 | -0.664 |
| P-value | Threshold |
|---|---|
| 0.001 | -0.60019 |
| 0.0005 | 1.03076 |
| 0.0001 | 4.42361 |