NR1H3.H14CORE.1.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NR1H3.H14CORE.1.P.B
Gene (human)	NR1H3 (GeneCards)
Gene synonyms (human)	LXRA
Gene (mouse)	Nr1h3
Gene synonyms (mouse)	Lxra
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	13
Consensus	bbhRRGGTCAbhv
GC content	51.15%
Information content (bits; total / per base)	9.616 / 0.74
Data sources	ChIP-Seq
Aligned words	1000
Previous names	NR1H3.H12CORE.1.P.B

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	3 (20)	0.702	0.766	0.541	0.592	0.679	0.743	1.752	2.033	34.213	75.62
Mouse	8 (49)	0.716	0.825	0.578	0.68	0.677	0.79	1.844	2.337	57.854	124.959

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	Nuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF family	Thyroid hormone receptor-related {2.1.2} (TFClass)
TF subfamily	LXR (NR1H) {2.1.2.7} (TFClass)
TFClass ID	TFClass: 2.1.2.7.1
HGNC	HGNC:7966
MGI	MGI:1352462
EntrezGene (human)	GeneID:10062 (SSTAR profile)
EntrezGene (mouse)	GeneID:22259 (SSTAR profile)
UniProt ID (human)	NR1H3_HUMAN
UniProt ID (mouse)	NR1H3_MOUSE
UniProt AC (human)	Q13133 (TFClass)
UniProt AC (mouse)	Q9Z0Y9 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	3 human, 8 mouse
HT-SELEX	0
Methyl-HT-SELEX	0
Genomic HT-SELEX	0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq	0
PBM	0

PCM	NR1H3.H14CORE.1.P.B.pcm
PWM	NR1H3.H14CORE.1.P.B.pwm
PFM	NR1H3.H14CORE.1.P.B.pfm
Threshold to P-value map	NR1H3.H14CORE.1.P.B.thr
Motif in other formats
JASPAR format	NR1H3.H14CORE.1.P.B_jaspar_format.txt
MEME format	NR1H3.H14CORE.1.P.B_meme_format.meme
Transfac format	NR1H3.H14CORE.1.P.B_transfac_format.txt
Homer format	NR1H3.H14CORE.1.P.B_homer_format_0.001.txt NR1H3.H14CORE.1.P.B_homer_format_0.0005.txt NR1H3.H14CORE.1.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	164.0	411.0	166.0	259.0
02	126.0	413.0	161.0	300.0
03	462.0	200.0	67.0	271.0
04	323.0	73.0	549.0	55.0
05	695.0	10.0	286.0	9.0
06	8.0	3.0	979.0	10.0
07	4.0	5.0	844.0	147.0
08	26.0	50.0	72.0	852.0
09	20.0	771.0	11.0	198.0
10	974.0	11.0	2.0	13.0
11	140.0	498.0	153.0	209.0
12	261.0	161.0	147.0	431.0
13	222.0	195.0	411.0	172.0

PFM

	A	C	G	T
01	0.164	0.411	0.166	0.259
02	0.126	0.413	0.161	0.3
03	0.462	0.2	0.067	0.271
04	0.323	0.073	0.549	0.055
05	0.695	0.01	0.286	0.009
06	0.008	0.003	0.979	0.01
07	0.004	0.005	0.844	0.147
08	0.026	0.05	0.072	0.852
09	0.02	0.771	0.011	0.198
10	0.974	0.011	0.002	0.013
11	0.14	0.498	0.153	0.209
12	0.261	0.161	0.147	0.431
13	0.222	0.195	0.411	0.172

PWM

	A	C	G	T
01	-0.418	0.494	-0.406	0.035
02	-0.678	0.499	-0.436	0.181
03	0.611	-0.221	-1.298	0.08
04	0.255	-1.215	0.783	-1.49
05	1.018	-3.066	0.134	-3.156
06	-3.253	-3.975	1.36	-3.066
07	-3.783	-3.622	1.212	-0.526
08	-2.206	-1.582	-1.228	1.221
09	-2.45	1.122	-2.985	-0.231
10	1.355	-2.985	-4.213	-2.839
11	-0.574	0.686	-0.487	-0.178
12	0.043	-0.436	-0.526	0.542
13	-0.118	-0.247	0.494	-0.371

Standard thresholds

P-value	Threshold
0.001	4.87431
0.0005	5.73891
0.0001	7.390565