| Motif | NFAC1.H14INVITRO.2.SM.B |
| Gene (human) | NFATC1 (GeneCards) |
| Gene synonyms (human) | NFAT2, NFATC |
| Gene (mouse) | Nfatc1 |
| Gene synonyms (mouse) | Nfat2, Nfatc |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 2 |
| Quality | B |
| Motif | NFAC1.H14INVITRO.2.SM.B |
| Gene (human) | NFATC1 (GeneCards) |
| Gene synonyms (human) | NFAT2, NFATC |
| Gene (mouse) | Nfatc1 |
| Gene synonyms (mouse) | Nfat2, Nfatc |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 2 |
| Quality | B |
| Motif length | 19 |
| Consensus | dWWhYnnbhRCGGAAAMWn |
| GC content | 39.31% |
| Information content (bits; total / per base) | 15.72 / 0.827 |
| Data sources | HT-SELEX + Methyl-HT-SELEX |
| Aligned words | 8933 |
| Previous names | NFAC1.H12INVITRO.2.SM.B |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Human | 3 (16) | 0.601 | 0.735 | 0.454 | 0.605 | 0.585 | 0.729 | 1.503 | 2.182 | 14.513 | 41.276 |
| Mouse | 3 (18) | 0.715 | 0.813 | 0.581 | 0.668 | 0.678 | 0.775 | 1.926 | 2.326 | 110.592 | 186.678 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 6 experiments | median | 0.957 | 0.939 | 0.884 | 0.866 | 0.737 | 0.751 |
| best | 1.0 | 1.0 | 0.998 | 0.997 | 0.965 | 0.964 | |
| Methyl HT-SELEX, 2 experiments | median | 0.991 | 0.988 | 0.972 | 0.964 | 0.882 | 0.887 |
| best | 1.0 | 1.0 | 0.998 | 0.997 | 0.965 | 0.964 | |
| Non-Methyl HT-SELEX, 4 experiments | median | 0.896 | 0.874 | 0.748 | 0.747 | 0.629 | 0.651 |
| best | 0.994 | 0.992 | 0.95 | 0.943 | 0.792 | 0.809 | |
| TF superclass | Immunoglobulin fold {6} (TFClass) |
| TF class | Rel homology region (RHR) factors {6.1} (TFClass) |
| TF family | NFAT-related {6.1.3} (TFClass) |
| TF subfamily | {6.1.3.0} (TFClass) |
| TFClass ID | TFClass: 6.1.3.0.1 |
| HGNC | HGNC:7775 |
| MGI | MGI:102469 |
| EntrezGene (human) | GeneID:4772 (SSTAR profile) |
| EntrezGene (mouse) | |
| UniProt ID (human) | NFAC1_HUMAN |
| UniProt ID (mouse) | NFAC1_MOUSE |
| UniProt AC (human) | O95644 (TFClass) |
| UniProt AC (mouse) | O88942 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 3 human, 3 mouse |
| HT-SELEX | 4 |
| Methyl-HT-SELEX | 2 |
| Genomic HT-SELEX | 0 overall: 0 Lysate, 0 IVT, 0 GFPIVT |
| SMiLE-Seq | 0 |
| PBM | 0 |
| PCM | NFAC1.H14INVITRO.2.SM.B.pcm |
| PWM | NFAC1.H14INVITRO.2.SM.B.pwm |
| PFM | NFAC1.H14INVITRO.2.SM.B.pfm |
| Threshold to P-value map | NFAC1.H14INVITRO.2.SM.B.thr |
| Motif in other formats | |
| JASPAR format | NFAC1.H14INVITRO.2.SM.B_jaspar_format.txt |
| MEME format | NFAC1.H14INVITRO.2.SM.B_meme_format.meme |
| Transfac format | NFAC1.H14INVITRO.2.SM.B_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 1680.25 | 1295.25 | 1609.25 | 4348.25 |
| 02 | 1349.75 | 968.75 | 977.75 | 5636.75 |
| 03 | 1178.0 | 749.0 | 718.0 | 6288.0 |
| 04 | 889.0 | 3237.0 | 719.0 | 4088.0 |
| 05 | 648.0 | 5252.0 | 530.0 | 2503.0 |
| 06 | 1514.0 | 3022.0 | 2233.0 | 2164.0 |
| 07 | 1545.0 | 1989.0 | 2050.0 | 3349.0 |
| 08 | 1335.0 | 3321.0 | 1379.0 | 2898.0 |
| 09 | 3464.0 | 2274.0 | 879.0 | 2316.0 |
| 10 | 6424.0 | 25.0 | 2250.0 | 234.0 |
| 11 | 2.0 | 6516.0 | 0.0 | 2415.0 |
| 12 | 0.0 | 0.0 | 8933.0 | 0.0 |
| 13 | 0.0 | 0.0 | 8933.0 | 0.0 |
| 14 | 8933.0 | 0.0 | 0.0 | 0.0 |
| 15 | 8933.0 | 0.0 | 0.0 | 0.0 |
| 16 | 8801.0 | 109.0 | 1.0 | 22.0 |
| 17 | 5587.0 | 1738.0 | 940.0 | 668.0 |
| 18 | 3032.5 | 480.5 | 327.5 | 5092.5 |
| 19 | 2662.5 | 1466.5 | 1796.5 | 3007.5 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.188 | 0.145 | 0.18 | 0.487 |
| 02 | 0.151 | 0.108 | 0.109 | 0.631 |
| 03 | 0.132 | 0.084 | 0.08 | 0.704 |
| 04 | 0.1 | 0.362 | 0.08 | 0.458 |
| 05 | 0.073 | 0.588 | 0.059 | 0.28 |
| 06 | 0.169 | 0.338 | 0.25 | 0.242 |
| 07 | 0.173 | 0.223 | 0.229 | 0.375 |
| 08 | 0.149 | 0.372 | 0.154 | 0.324 |
| 09 | 0.388 | 0.255 | 0.098 | 0.259 |
| 10 | 0.719 | 0.003 | 0.252 | 0.026 |
| 11 | 0.0 | 0.729 | 0.0 | 0.27 |
| 12 | 0.0 | 0.0 | 1.0 | 0.0 |
| 13 | 0.0 | 0.0 | 1.0 | 0.0 |
| 14 | 1.0 | 0.0 | 0.0 | 0.0 |
| 15 | 1.0 | 0.0 | 0.0 | 0.0 |
| 16 | 0.985 | 0.012 | 0.0 | 0.002 |
| 17 | 0.625 | 0.195 | 0.105 | 0.075 |
| 18 | 0.339 | 0.054 | 0.037 | 0.57 |
| 19 | 0.298 | 0.164 | 0.201 | 0.337 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | -0.284 | -0.544 | -0.327 | 0.666 |
| 02 | -0.503 | -0.834 | -0.825 | 0.925 |
| 03 | -0.639 | -1.09 | -1.133 | 1.035 |
| 04 | -0.92 | 0.371 | -1.131 | 0.604 |
| 05 | -1.235 | 0.855 | -1.435 | 0.114 |
| 06 | -0.388 | 0.302 | -0.0 | -0.031 |
| 07 | -0.368 | -0.116 | -0.086 | 0.405 |
| 08 | -0.514 | 0.396 | -0.481 | 0.26 |
| 09 | 0.439 | 0.018 | -0.931 | 0.036 |
| 10 | 1.056 | -4.406 | 0.007 | -2.247 |
| 11 | -6.26 | 1.07 | -6.891 | 0.078 |
| 12 | -6.891 | -6.891 | 1.386 | -6.891 |
| 13 | -6.891 | -6.891 | 1.386 | -6.891 |
| 14 | 1.386 | -6.891 | -6.891 | -6.891 |
| 15 | 1.386 | -6.891 | -6.891 | -6.891 |
| 16 | 1.371 | -3.0 | -6.526 | -4.523 |
| 17 | 0.916 | -0.25 | -0.864 | -1.205 |
| 18 | 0.306 | -1.533 | -1.914 | 0.824 |
| 19 | 0.176 | -0.42 | -0.217 | 0.297 |
| P-value | Threshold |
|---|---|
| 0.001 | 0.35276 |
| 0.0005 | 2.14256 |
| 0.0001 | 6.14891 |