MEF2D.H14CORE.0.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	MEF2D.H14CORE.0.PS.A
Gene (human)	MEF2D (GeneCards)
Gene synonyms (human)
Gene (mouse)	Mef2d
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	13
Consensus	dKCTATTTWWAKh
GC content	30.98%
Information content (bits; total / per base)	13.389 / 1.03
Data sources	ChIP-Seq + HT-SELEX
Aligned words	998
Previous names	MEF2D.H12CORE.0.PS.A

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.706	0.734	0.665	0.689	0.788	0.807	3.627	3.718	111.0	130.444
Mouse	8 (46)	0.936	0.963	0.898	0.932	0.949	0.975	5.05	5.444	317.067	620.62

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 3 experiments	median	0.79	0.745	0.685	0.662	0.581	0.601
Overall, 3 experiments	best	0.942	0.939	0.717	0.751	0.599	0.636
Methyl HT-SELEX, 1 experiments	median	0.79	0.745	0.685	0.662	0.599	0.601
Methyl HT-SELEX, 1 experiments	best	0.79	0.745	0.685	0.662	0.599	0.601
Non-Methyl HT-SELEX, 2 experiments	median	0.828	0.831	0.649	0.68	0.555	0.597
Non-Methyl HT-SELEX, 2 experiments	best	0.942	0.939	0.717	0.751	0.581	0.636

TF superclass	alpha-Helices exposed by beta-structures {5} (TFClass)
TF class	MADS box factors {5.1} (TFClass)
TF family	Regulators of differentiation {5.1.1} (TFClass)
TF subfamily	MEF2 {5.1.1.1} (TFClass)
TFClass ID	TFClass: 5.1.1.1.4
HGNC	HGNC:6997
MGI	MGI:99533
EntrezGene (human)	GeneID:4209 (SSTAR profile)
EntrezGene (mouse)	GeneID:17261 (SSTAR profile)
UniProt ID (human)	MEF2D_HUMAN
UniProt ID (mouse)	MEF2D_MOUSE
UniProt AC (human)	Q14814 (TFClass)
UniProt AC (mouse)	Q63943 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 8 mouse
HT-SELEX	2
Methyl-HT-SELEX	1
Genomic HT-SELEX	0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq	0
PBM	0

PCM	MEF2D.H14CORE.0.PS.A.pcm
PWM	MEF2D.H14CORE.0.PS.A.pwm
PFM	MEF2D.H14CORE.0.PS.A.pfm
Threshold to P-value map	MEF2D.H14CORE.0.PS.A.thr
Motif in other formats
JASPAR format	MEF2D.H14CORE.0.PS.A_jaspar_format.txt
MEME format	MEF2D.H14CORE.0.PS.A_meme_format.meme
Transfac format	MEF2D.H14CORE.0.PS.A_transfac_format.txt
Homer format	MEF2D.H14CORE.0.PS.A_homer_format_0.001.txt MEF2D.H14CORE.0.PS.A_homer_format_0.0005.txt MEF2D.H14CORE.0.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	260.0	57.0	348.0	333.0
02	69.0	71.0	534.0	324.0
03	21.0	830.0	32.0	115.0
04	1.0	24.0	0.0	973.0
05	982.0	6.0	6.0	4.0
06	92.0	6.0	4.0	896.0
07	86.0	7.0	9.0	896.0
08	49.0	71.0	10.0	868.0
09	217.0	93.0	12.0	676.0
10	120.0	27.0	118.0	733.0
11	618.0	0.0	375.0	5.0
12	75.0	39.0	795.0	89.0
13	312.0	440.0	105.0	141.0

PFM

	A	C	G	T
01	0.261	0.057	0.349	0.334
02	0.069	0.071	0.535	0.325
03	0.021	0.832	0.032	0.115
04	0.001	0.024	0.0	0.975
05	0.984	0.006	0.006	0.004
06	0.092	0.006	0.004	0.898
07	0.086	0.007	0.009	0.898
08	0.049	0.071	0.01	0.87
09	0.217	0.093	0.012	0.677
10	0.12	0.027	0.118	0.734
11	0.619	0.0	0.376	0.005
12	0.075	0.039	0.797	0.089
13	0.313	0.441	0.105	0.141

PWM

	A	C	G	T
01	0.041	-1.453	0.331	0.287
02	-1.268	-1.24	0.757	0.26
03	-2.403	1.197	-2.008	-0.767
04	-4.523	-2.279	-4.98	1.356
05	1.365	-3.482	-3.482	-3.781
06	-0.986	-3.482	-3.781	1.274
07	-1.052	-3.36	-3.154	1.274
08	-1.6	-1.24	-3.065	1.242
09	-0.139	-0.975	-2.907	0.992
10	-0.725	-2.169	-0.741	1.073
11	0.903	-4.98	0.405	-3.62
12	-1.186	-1.819	1.154	-1.019
13	0.222	0.564	-0.856	-0.565

Standard thresholds

P-value	Threshold
0.001	3.64396
0.0005	4.73791
0.0001	6.97368