| Motif | MEF2C.H14CORE.1.SM.B |
| Gene (human) | MEF2C (GeneCards) |
| Gene synonyms (human) | |
| Gene (mouse) | Mef2c |
| Gene synonyms (mouse) | |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 1 |
| Quality | B |
| Motif | MEF2C.H14CORE.1.SM.B |
| Gene (human) | MEF2C (GeneCards) |
| Gene synonyms (human) | |
| Gene (mouse) | Mef2c |
| Gene synonyms (mouse) | |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 1 |
| Quality | B |
| Motif length | 17 |
| Consensus | ndMCvnATTWGGhWhvn |
| GC content | 42.36% |
| Information content (bits; total / per base) | 11.32 / 0.666 |
| Data sources | HT-SELEX + Methyl-HT-SELEX |
| Aligned words | 8733 |
| Previous names | MEF2C.H12CORE.1.SM.B |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Human | 2 (12) | 0.636 | 0.697 | 0.49 | 0.51 | 0.555 | 0.629 | 1.334 | 1.501 | 24.461 | 59.77 |
| Mouse | 12 (78) | 0.716 | 0.738 | 0.542 | 0.594 | 0.627 | 0.651 | 1.503 | 1.633 | 38.916 | 184.854 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 2 experiments | median | 0.98 | 0.97 | 0.925 | 0.909 | 0.775 | 0.785 |
| best | 0.981 | 0.971 | 0.931 | 0.915 | 0.789 | 0.795 | |
| Methyl HT-SELEX, 1 experiments | median | 0.979 | 0.969 | 0.919 | 0.903 | 0.762 | 0.775 |
| best | 0.979 | 0.969 | 0.919 | 0.903 | 0.762 | 0.775 | |
| Non-Methyl HT-SELEX, 1 experiments | median | 0.981 | 0.971 | 0.931 | 0.915 | 0.789 | 0.795 |
| best | 0.981 | 0.971 | 0.931 | 0.915 | 0.789 | 0.795 | |
| rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
|---|---|---|---|---|
| batch 1 | 0.961 | 0.397 | 0.881 | 0.636 |
| batch 2 | 0.575 | 0.049 | 0.361 | 0.222 |
| TF superclass | alpha-Helices exposed by beta-structures {5} (TFClass) |
| TF class | MADS box factors {5.1} (TFClass) |
| TF family | Regulators of differentiation {5.1.1} (TFClass) |
| TF subfamily | MEF2 {5.1.1.1} (TFClass) |
| TFClass ID | TFClass: 5.1.1.1.3 |
| HGNC | HGNC:6996 |
| MGI | MGI:99458 |
| EntrezGene (human) | GeneID:4208 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:17260 (SSTAR profile) |
| UniProt ID (human) | MEF2C_HUMAN |
| UniProt ID (mouse) | MEF2C_MOUSE |
| UniProt AC (human) | Q06413 (TFClass) |
| UniProt AC (mouse) | Q8CFN5 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 2 human, 12 mouse |
| HT-SELEX | 1 |
| Methyl-HT-SELEX | 1 |
| Genomic HT-SELEX | 0 overall: 0 Lysate, 0 IVT, 0 GFPIVT |
| SMiLE-Seq | 0 |
| PBM | 0 |
| PCM | MEF2C.H14CORE.1.SM.B.pcm |
| PWM | MEF2C.H14CORE.1.SM.B.pwm |
| PFM | MEF2C.H14CORE.1.SM.B.pfm |
| Threshold to P-value map | MEF2C.H14CORE.1.SM.B.thr |
| Motif in other formats | |
| JASPAR format | MEF2C.H14CORE.1.SM.B_jaspar_format.txt |
| MEME format | MEF2C.H14CORE.1.SM.B_meme_format.meme |
| Transfac format | MEF2C.H14CORE.1.SM.B_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 1985.5 | 1630.5 | 2285.5 | 2831.5 |
| 02 | 1083.25 | 832.25 | 3174.25 | 3643.25 |
| 03 | 2307.0 | 5712.0 | 250.0 | 464.0 |
| 04 | 95.0 | 6638.0 | 74.0 | 1926.0 |
| 05 | 3209.0 | 2672.0 | 1608.0 | 1244.0 |
| 06 | 3248.0 | 1367.0 | 2180.0 | 1938.0 |
| 07 | 6662.0 | 33.0 | 161.0 | 1877.0 |
| 08 | 509.0 | 3.0 | 21.0 | 8200.0 |
| 09 | 1967.0 | 15.0 | 37.0 | 6714.0 |
| 10 | 2725.0 | 37.0 | 86.0 | 5885.0 |
| 11 | 1624.0 | 1.0 | 7107.0 | 1.0 |
| 12 | 5.0 | 13.0 | 8648.0 | 67.0 |
| 13 | 4125.0 | 1652.0 | 975.0 | 1981.0 |
| 14 | 5413.0 | 859.0 | 796.0 | 1665.0 |
| 15 | 3400.0 | 2828.0 | 1133.0 | 1372.0 |
| 16 | 1629.75 | 3745.75 | 1958.75 | 1398.75 |
| 17 | 2543.25 | 1802.25 | 2548.25 | 1839.25 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.227 | 0.187 | 0.262 | 0.324 |
| 02 | 0.124 | 0.095 | 0.363 | 0.417 |
| 03 | 0.264 | 0.654 | 0.029 | 0.053 |
| 04 | 0.011 | 0.76 | 0.008 | 0.221 |
| 05 | 0.367 | 0.306 | 0.184 | 0.142 |
| 06 | 0.372 | 0.157 | 0.25 | 0.222 |
| 07 | 0.763 | 0.004 | 0.018 | 0.215 |
| 08 | 0.058 | 0.0 | 0.002 | 0.939 |
| 09 | 0.225 | 0.002 | 0.004 | 0.769 |
| 10 | 0.312 | 0.004 | 0.01 | 0.674 |
| 11 | 0.186 | 0.0 | 0.814 | 0.0 |
| 12 | 0.001 | 0.001 | 0.99 | 0.008 |
| 13 | 0.472 | 0.189 | 0.112 | 0.227 |
| 14 | 0.62 | 0.098 | 0.091 | 0.191 |
| 15 | 0.389 | 0.324 | 0.13 | 0.157 |
| 16 | 0.187 | 0.429 | 0.224 | 0.16 |
| 17 | 0.291 | 0.206 | 0.292 | 0.211 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | -0.095 | -0.292 | 0.046 | 0.26 |
| 02 | -0.7 | -0.963 | 0.374 | 0.512 |
| 03 | 0.055 | 0.961 | -2.159 | -1.545 |
| 04 | -3.112 | 1.111 | -3.355 | -0.125 |
| 05 | 0.385 | 0.202 | -0.305 | -0.562 |
| 06 | 0.397 | -0.468 | -0.001 | -0.119 |
| 07 | 1.115 | -4.127 | -2.594 | -0.151 |
| 08 | -1.453 | -6.028 | -4.542 | 1.323 |
| 09 | -0.104 | -4.841 | -4.019 | 1.123 |
| 10 | 0.221 | -4.019 | -3.209 | 0.991 |
| 11 | -0.296 | -6.505 | 1.18 | -6.505 |
| 12 | -5.706 | -4.964 | 1.376 | -3.452 |
| 13 | 0.636 | -0.278 | -0.805 | -0.097 |
| 14 | 0.907 | -0.931 | -1.007 | -0.271 |
| 15 | 0.443 | 0.259 | -0.655 | -0.464 |
| 16 | -0.292 | 0.539 | -0.108 | -0.445 |
| 17 | 0.152 | -0.192 | 0.154 | -0.171 |
| P-value | Threshold |
|---|---|
| 0.001 | 4.34856 |
| 0.0005 | 5.42451 |
| 0.0001 | 7.42271 |