| Motif | MEF2B.H14INVITRO.1.SM.B |
| Gene (human) | MEF2B (GeneCards) |
| Gene synonyms (human) | XMEF2 |
| Gene (mouse) | Mef2b |
| Gene synonyms (mouse) | |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 1 |
| Quality | B |
| Motif | MEF2B.H14INVITRO.1.SM.B |
| Gene (human) | MEF2B (GeneCards) |
| Gene synonyms (human) | XMEF2 |
| Gene (mouse) | Mef2b |
| Gene synonyms (mouse) | |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 1 |
| Quality | B |
| Motif length | 16 |
| Consensus | nhSdWdCCWWATnbGb |
| GC content | 45.62% |
| Information content (bits; total / per base) | 10.954 / 0.685 |
| Data sources | HT-SELEX + Methyl-HT-SELEX |
| Aligned words | 9978 |
| Previous names | MEF2B.H12INVITRO.1.SM.B |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Human | 16 (100) | 0.655 | 0.713 | 0.469 | 0.546 | 0.541 | 0.605 | 1.224 | 1.477 | 32.529 | 92.194 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 3 experiments | median | 0.995 | 0.993 | 0.979 | 0.972 | 0.918 | 0.91 |
| best | 0.997 | 0.996 | 0.982 | 0.977 | 0.938 | 0.924 | |
| Methyl HT-SELEX, 1 experiments | median | 0.997 | 0.996 | 0.982 | 0.977 | 0.918 | 0.91 |
| best | 0.997 | 0.996 | 0.982 | 0.977 | 0.918 | 0.91 | |
| Non-Methyl HT-SELEX, 2 experiments | median | 0.744 | 0.745 | 0.735 | 0.734 | 0.714 | 0.71 |
| best | 0.995 | 0.993 | 0.979 | 0.972 | 0.938 | 0.924 | |
| rSNP benchmarking, ADASTRA | odds-ratio | -log-Fisher's P | Pearson r | Kendall tau |
|---|---|---|---|---|
| # | 1.825 | 1.693 | 0.104 | 0.071 |
| rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
|---|---|---|---|---|
| batch 1 | 0.728 | 0.33 | 0.525 | 0.322 |
| batch 2 | 0.697 | 0.225 | 0.56 | 0.499 |
| TF superclass | alpha-Helices exposed by beta-structures {5} (TFClass) |
| TF class | MADS box factors {5.1} (TFClass) |
| TF family | Regulators of differentiation {5.1.1} (TFClass) |
| TF subfamily | MEF2 {5.1.1.1} (TFClass) |
| TFClass ID | TFClass: 5.1.1.1.2 |
| HGNC | HGNC:6995 |
| MGI | MGI:104526 |
| EntrezGene (human) | GeneID:100271849 (SSTAR profile) GeneID:4207 (SSTAR profile) |
| EntrezGene (mouse) | |
| UniProt ID (human) | MEF2B_HUMAN |
| UniProt ID (mouse) | MEF2B_MOUSE |
| UniProt AC (human) | Q02080 (TFClass) |
| UniProt AC (mouse) | O55087 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 16 human, 0 mouse |
| HT-SELEX | 2 |
| Methyl-HT-SELEX | 1 |
| Genomic HT-SELEX | 0 overall: 0 Lysate, 0 IVT, 0 GFPIVT |
| SMiLE-Seq | 0 |
| PBM | 0 |
| PCM | MEF2B.H14INVITRO.1.SM.B.pcm |
| PWM | MEF2B.H14INVITRO.1.SM.B.pwm |
| PFM | MEF2B.H14INVITRO.1.SM.B.pfm |
| Threshold to P-value map | MEF2B.H14INVITRO.1.SM.B.thr |
| Motif in other formats | |
| JASPAR format | MEF2B.H14INVITRO.1.SM.B_jaspar_format.txt |
| MEME format | MEF2B.H14INVITRO.1.SM.B_meme_format.meme |
| Transfac format | MEF2B.H14INVITRO.1.SM.B_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 2504.0 | 2869.0 | 2690.0 | 1915.0 |
| 02 | 1678.25 | 2810.25 | 1197.25 | 4292.25 |
| 03 | 916.0 | 1639.0 | 6624.0 | 799.0 |
| 04 | 1587.0 | 1077.0 | 1856.0 | 5458.0 |
| 05 | 1085.0 | 552.0 | 658.0 | 7683.0 |
| 06 | 5104.0 | 996.0 | 1907.0 | 1971.0 |
| 07 | 25.0 | 9947.0 | 6.0 | 0.0 |
| 08 | 1.0 | 9688.0 | 27.0 | 262.0 |
| 09 | 6068.0 | 1541.0 | 736.0 | 1633.0 |
| 10 | 5070.0 | 297.0 | 772.0 | 3839.0 |
| 11 | 8746.0 | 39.0 | 44.0 | 1149.0 |
| 12 | 2187.0 | 240.0 | 63.0 | 7488.0 |
| 13 | 2902.0 | 2228.0 | 1478.0 | 3370.0 |
| 14 | 1157.0 | 2330.0 | 3245.0 | 3246.0 |
| 15 | 924.5 | 295.5 | 8472.5 | 285.5 |
| 16 | 1353.5 | 1375.5 | 5126.5 | 2122.5 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.251 | 0.288 | 0.27 | 0.192 |
| 02 | 0.168 | 0.282 | 0.12 | 0.43 |
| 03 | 0.092 | 0.164 | 0.664 | 0.08 |
| 04 | 0.159 | 0.108 | 0.186 | 0.547 |
| 05 | 0.109 | 0.055 | 0.066 | 0.77 |
| 06 | 0.512 | 0.1 | 0.191 | 0.198 |
| 07 | 0.003 | 0.997 | 0.001 | 0.0 |
| 08 | 0.0 | 0.971 | 0.003 | 0.026 |
| 09 | 0.608 | 0.154 | 0.074 | 0.164 |
| 10 | 0.508 | 0.03 | 0.077 | 0.385 |
| 11 | 0.877 | 0.004 | 0.004 | 0.115 |
| 12 | 0.219 | 0.024 | 0.006 | 0.75 |
| 13 | 0.291 | 0.223 | 0.148 | 0.338 |
| 14 | 0.116 | 0.234 | 0.325 | 0.325 |
| 15 | 0.093 | 0.03 | 0.849 | 0.029 |
| 16 | 0.136 | 0.138 | 0.514 | 0.213 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.004 | 0.14 | 0.075 | -0.264 |
| 02 | -0.396 | 0.119 | -0.733 | 0.542 |
| 03 | -1.0 | -0.42 | 0.976 | -1.137 |
| 04 | -0.452 | -0.839 | -0.295 | 0.782 |
| 05 | -0.831 | -1.505 | -1.33 | 1.124 |
| 06 | 0.715 | -0.917 | -0.268 | -0.235 |
| 07 | -4.516 | 1.382 | -5.706 | -6.989 |
| 08 | -6.628 | 1.356 | -4.445 | -2.246 |
| 09 | 0.888 | -0.481 | -1.218 | -0.423 |
| 10 | 0.709 | -2.121 | -1.171 | 0.431 |
| 11 | 1.254 | -4.102 | -3.988 | -0.774 |
| 12 | -0.131 | -2.333 | -3.644 | 1.099 |
| 13 | 0.151 | -0.113 | -0.523 | 0.301 |
| 14 | -0.767 | -0.068 | 0.263 | 0.263 |
| 15 | -0.991 | -2.126 | 1.222 | -2.16 |
| 16 | -0.611 | -0.595 | 0.72 | -0.161 |
| P-value | Threshold |
|---|---|
| 0.001 | 4.53546 |
| 0.0005 | 5.45826 |
| 0.0001 | 7.28616 |