MAX.H14INVIVO.2.S.C motif - HOmo sapiens COmprehensive MOdel COllection

Motif	MAX.H14INVIVO.2.S.C
Gene (human)	MAX (GeneCards)
Gene synonyms (human)	BHLHD4
Gene (mouse)	Max
Gene synonyms (mouse)	Myn
LOGO
LOGO (reverse complement)
Motif subtype	2
Quality	C

Motif length	25
Consensus	nbMMSKKKnhhdSCACGTGvbnnnn
GC content	57.9%
Information content (bits; total / per base)	18.076 / 0.723
Data sources	HT-SELEX
Aligned words	267
Previous names	MAX.H12INVIVO.2.S.C

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	39 (261)	0.833	0.949	0.75	0.908	0.756	0.887	2.464	3.323	141.26	455.921
Mouse	6 (39)	0.828	0.9	0.736	0.852	0.749	0.83	2.387	2.941	128.886	365.119

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.996	0.994	0.982	0.978	0.911	0.89
Overall, 6 experiments	best	1.0	0.999	0.999	0.998	0.996	0.995
Methyl HT-SELEX, 1 experiments	median	0.959	0.94	0.924	0.895	0.862	0.831
Methyl HT-SELEX, 1 experiments	best	0.959	0.94	0.924	0.895	0.862	0.831
Non-Methyl HT-SELEX, 5 experiments	median	0.997	0.996	0.988	0.982	0.96	0.949
Non-Methyl HT-SELEX, 5 experiments	best	1.0	0.999	0.999	0.998	0.996	0.995

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	28.632	23.366	0.287	0.253

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	bHLH-ZIP {1.2.6} (TFClass)
TF subfamily	MYC {1.2.6.5} (TFClass)
TFClass ID	TFClass: 1.2.6.5.5
HGNC	HGNC:6913
MGI	MGI:96921
EntrezGene (human)	GeneID:4149 (SSTAR profile)
EntrezGene (mouse)	GeneID:17187 (SSTAR profile)
UniProt ID (human)	MAX_HUMAN
UniProt ID (mouse)	MAX_MOUSE
UniProt AC (human)	P61244 (TFClass)
UniProt AC (mouse)	P28574 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	39 human, 6 mouse
HT-SELEX	5
Methyl-HT-SELEX	1
Genomic HT-SELEX	0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq	0
PBM	0

PCM	MAX.H14INVIVO.2.S.C.pcm
PWM	MAX.H14INVIVO.2.S.C.pwm
PFM	MAX.H14INVIVO.2.S.C.pfm
Threshold to P-value map	MAX.H14INVIVO.2.S.C.thr
Motif in other formats
JASPAR format	MAX.H14INVIVO.2.S.C_jaspar_format.txt
MEME format	MAX.H14INVIVO.2.S.C_meme_format.meme
Transfac format	MAX.H14INVIVO.2.S.C_transfac_format.txt
Homer format	MAX.H14INVIVO.2.S.C_homer_format_0.001.txt MAX.H14INVIVO.2.S.C_homer_format_0.0005.txt MAX.H14INVIVO.2.S.C_homer_format_0.0001.txt

PCM

	A	C	G	T
01	73.25	68.25	74.25	51.25
02	40.0	127.0	54.0	46.0
03	70.0	165.0	21.0	11.0
04	168.0	54.0	34.0	11.0
05	3.0	185.0	62.0	17.0
06	9.0	9.0	195.0	54.0
07	9.0	31.0	46.0	181.0
08	10.0	17.0	208.0	32.0
09	60.0	86.0	53.0	68.0
10	70.0	50.0	40.0	107.0
11	112.0	42.0	33.0	80.0
12	115.0	45.0	59.0	48.0
13	14.0	149.0	68.0	36.0
14	0.0	267.0	0.0	0.0
15	267.0	0.0	0.0	0.0
16	0.0	267.0	0.0	0.0
17	0.0	0.0	267.0	0.0
18	0.0	1.0	0.0	266.0
19	0.0	0.0	266.0	1.0
20	59.0	77.0	108.0	23.0
21	29.0	55.0	31.0	152.0
22	59.0	77.0	37.0	94.0
23	60.0	92.0	47.0	68.0
24	63.25	103.25	48.25	52.25
25	59.5	85.5	60.5	61.5

PFM

	A	C	G	T
01	0.274	0.256	0.278	0.192
02	0.15	0.476	0.202	0.172
03	0.262	0.618	0.079	0.041
04	0.629	0.202	0.127	0.041
05	0.011	0.693	0.232	0.064
06	0.034	0.034	0.73	0.202
07	0.034	0.116	0.172	0.678
08	0.037	0.064	0.779	0.12
09	0.225	0.322	0.199	0.255
10	0.262	0.187	0.15	0.401
11	0.419	0.157	0.124	0.3
12	0.431	0.169	0.221	0.18
13	0.052	0.558	0.255	0.135
14	0.0	1.0	0.0	0.0
15	1.0	0.0	0.0	0.0
16	0.0	1.0	0.0	0.0
17	0.0	0.0	1.0	0.0
18	0.0	0.004	0.0	0.996
19	0.0	0.0	0.996	0.004
20	0.221	0.288	0.404	0.086
21	0.109	0.206	0.116	0.569
22	0.221	0.288	0.139	0.352
23	0.225	0.345	0.176	0.255
24	0.237	0.387	0.181	0.196
25	0.223	0.32	0.227	0.23

PWM

	A	C	G	T
01	0.091	0.022	0.104	-0.258
02	-0.498	0.633	-0.207	-0.363
03	0.047	0.893	-1.113	-1.704
04	0.911	-0.207	-0.655	-1.704
05	-2.741	1.006	-0.072	-1.309
06	-1.88	-1.88	1.058	-0.207
07	-1.88	-0.744	-0.363	0.985
08	-1.788	-1.309	1.123	-0.713
09	-0.104	0.249	-0.225	0.018
10	0.047	-0.282	-0.498	0.464
11	0.509	-0.451	-0.684	0.178
12	0.535	-0.384	-0.121	-0.322
13	-1.488	0.792	0.018	-0.6
14	-3.887	1.371	-3.887	-3.887
15	1.371	-3.887	-3.887	-3.887
16	-3.887	1.371	-3.887	-3.887
17	-3.887	-3.887	1.371	-3.887
18	-3.887	-3.348	-3.887	1.367
19	-3.887	-3.887	1.367	-3.348
20	-0.121	0.14	0.473	-1.027
21	-0.807	-0.189	-0.744	0.811
22	-0.121	0.14	-0.574	0.336
23	-0.104	0.315	-0.342	0.018
24	-0.053	0.429	-0.317	-0.239
25	-0.112	0.243	-0.096	-0.08

Standard thresholds

P-value	Threshold
0.001	1.49111
0.0005	2.86351
0.0001	5.73281