MotifITF2.H14RSNP.0.S.B
Gene (human)TCF4
(GeneCards)
Gene synonyms (human)BHLHB19, ITF2, SEF2
Gene (mouse)Tcf4
Gene synonyms (mouse)Itf2, Sef2
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
B
Motif length17
ConsensusnvSWGGTGCAGGTGYdn
GC content60.13%
Information content (bits; total / per base)18.458 / 1.086
Data sourcesHT-SELEX
Aligned words176
Previous namesITF2.H12RSNP.0.S.B

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 8 (55) 0.846 0.893 0.661 0.728 0.739 0.873 1.989 3.205 76.215 121.174

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 6 experiments median 0.973 0.951 0.96 0.936 0.915 0.889
best 0.996 0.992 0.994 0.989 0.982 0.975
Methyl HT-SELEX, 1 experiments median 0.973 0.952 0.962 0.937 0.921 0.894
best 0.973 0.952 0.962 0.937 0.921 0.894
Non-Methyl HT-SELEX, 5 experiments median 0.972 0.951 0.959 0.934 0.91 0.883
best 0.996 0.992 0.994 0.989 0.982 0.975

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 3.011 13.672 0.143 0.125
TF superclassBasic domains {1} (TFClass)
TF classBasic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF familyE2A {1.2.1} (TFClass)
TF subfamilyE2A-like {1.2.1.0} (TFClass)
TFClass IDTFClass: 1.2.1.0.2
HGNCHGNC:11634
MGIMGI:98506
EntrezGene (human)GeneID:6925
(SSTAR profile)
EntrezGene (mouse)GeneID:21413
(SSTAR profile)
UniProt ID (human)ITF2_HUMAN
UniProt ID (mouse)ITF2_MOUSE
UniProt AC (human)P15884
(TFClass)
UniProt AC (mouse)Q60722
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 8 human, 0 mouse
HT-SELEX 5
Methyl-HT-SELEX 1
Genomic HT-SELEX 0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq 0
PBM 0
PCM
ACGT
0131.551.551.541.5
0232.050.068.026.0
031.0124.041.010.0
04122.013.018.023.0
057.05.0142.022.0
0611.01.0148.016.0
077.019.00.0150.0
089.08.0159.00.0
090.0176.00.00.0
10176.00.00.00.0
110.032.0144.00.0
120.032.0144.00.0
130.00.00.0176.0
140.00.0176.00.0
150.049.06.0121.0
1628.7515.7548.7582.75
1733.7534.7541.7565.75
PFM
ACGT
010.1790.2930.2930.236
020.1820.2840.3860.148
030.0060.7050.2330.057
040.6930.0740.1020.131
050.040.0280.8070.125
060.0630.0060.8410.091
070.040.1080.00.852
080.0510.0450.9030.0
090.01.00.00.0
101.00.00.00.0
110.00.1820.8180.0
120.00.1820.8180.0
130.00.00.01.0
140.00.01.00.0
150.00.2780.0340.688
160.1630.0890.2770.47
170.1920.1970.2370.374
PWM
ACGT
01-0.3230.1530.153-0.057
02-0.3080.1240.425-0.507
03-2.9831.018-0.069-1.389
041.001-1.153-0.853-0.623
05-1.698-1.9741.152-0.665
06-1.304-2.9831.193-0.963
07-1.698-0.803-3.5561.206
08-1.482-1.5841.264-3.556
09-3.5561.365-3.556-3.556
101.365-3.556-3.556-3.556
11-3.556-0.3081.166-3.556
12-3.556-0.3081.166-3.556
13-3.556-3.556-3.5561.365
14-3.556-3.5561.365-3.556
15-3.5560.105-1.8260.993
16-0.411-0.9770.10.618
17-0.257-0.228-0.0510.392
Standard thresholds
P-value Threshold
0.001 1.72716
0.0005 3.04826
0.0001 5.82121