| Motif | IRF8.H14INVIVO.0.P.B |
| Gene (human) | IRF8 (GeneCards) |
| Gene synonyms (human) | ICSBP1 |
| Gene (mouse) | Irf8 |
| Gene synonyms (mouse) | Icsbp, Icsbp1 |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 0 |
| Quality | B |
| Motif | IRF8.H14INVIVO.0.P.B |
| Gene (human) | IRF8 (GeneCards) |
| Gene synonyms (human) | ICSBP1 |
| Gene (mouse) | Irf8 |
| Gene synonyms (mouse) | Icsbp, Icsbp1 |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 0 |
| Quality | B |
| Motif length | 19 |
| Consensus | vdWWRRGGAASTGARMvhn |
| GC content | 45.21% |
| Information content (bits; total / per base) | 15.905 / 0.837 |
| Data sources | ChIP-Seq |
| Aligned words | 1010 |
| Previous names | IRF8.H12INVIVO.0.P.B |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mouse | 27 (157) | 0.945 | 0.983 | 0.898 | 0.97 | 0.962 | 0.988 | 5.048 | 6.671 | 353.638 | 919.292 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 7 experiments | median | 0.87 | 0.833 | 0.738 | 0.721 | 0.638 | 0.641 |
| best | 0.983 | 0.971 | 0.953 | 0.935 | 0.9 | 0.873 | |
| Methyl HT-SELEX, 2 experiments | median | 0.801 | 0.776 | 0.757 | 0.738 | 0.686 | 0.679 |
| best | 0.973 | 0.953 | 0.939 | 0.915 | 0.833 | 0.821 | |
| Non-Methyl HT-SELEX, 5 experiments | median | 0.87 | 0.833 | 0.738 | 0.721 | 0.638 | 0.641 |
| best | 0.983 | 0.971 | 0.953 | 0.935 | 0.9 | 0.873 | |
| rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
|---|---|---|---|---|
| batch 1 | 0.792 | 0.231 | 0.475 | 0.297 |
| batch 2 | 0.656 | 0.328 | 0.45 | 0.337 |
| TF superclass | Helix-turn-helix domains {3} (TFClass) |
| TF class | Tryptophan cluster factors {3.5} (TFClass) |
| TF family | IRF {3.5.3} (TFClass) |
| TF subfamily | {3.5.3.0} (TFClass) |
| TFClass ID | TFClass: 3.5.3.0.8 |
| HGNC | HGNC:5358 |
| MGI | MGI:96395 |
| EntrezGene (human) | GeneID:3394 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:15900 (SSTAR profile) |
| UniProt ID (human) | IRF8_HUMAN |
| UniProt ID (mouse) | IRF8_MOUSE |
| UniProt AC (human) | Q02556 (TFClass) |
| UniProt AC (mouse) | P23611 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 0 human, 27 mouse |
| HT-SELEX | 5 |
| Methyl-HT-SELEX | 2 |
| Genomic HT-SELEX | 0 overall: 0 Lysate, 0 IVT, 0 GFPIVT |
| SMiLE-Seq | 0 |
| PBM | 0 |
| PCM | IRF8.H14INVIVO.0.P.B.pcm |
| PWM | IRF8.H14INVIVO.0.P.B.pwm |
| PFM | IRF8.H14INVIVO.0.P.B.pfm |
| Threshold to P-value map | IRF8.H14INVIVO.0.P.B.thr |
| Motif in other formats | |
| JASPAR format | IRF8.H14INVIVO.0.P.B_jaspar_format.txt |
| MEME format | IRF8.H14INVIVO.0.P.B_meme_format.meme |
| Transfac format | IRF8.H14INVIVO.0.P.B_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 373.0 | 171.0 | 338.0 | 128.0 |
| 02 | 547.0 | 94.0 | 206.0 | 163.0 |
| 03 | 647.0 | 76.0 | 130.0 | 157.0 |
| 04 | 593.0 | 25.0 | 156.0 | 236.0 |
| 05 | 228.0 | 124.0 | 625.0 | 33.0 |
| 06 | 539.0 | 111.0 | 333.0 | 27.0 |
| 07 | 170.0 | 0.0 | 838.0 | 2.0 |
| 08 | 50.0 | 1.0 | 959.0 | 0.0 |
| 09 | 1003.0 | 3.0 | 2.0 | 2.0 |
| 10 | 993.0 | 2.0 | 5.0 | 10.0 |
| 11 | 77.0 | 289.0 | 638.0 | 6.0 |
| 12 | 69.0 | 64.0 | 14.0 | 863.0 |
| 13 | 14.0 | 1.0 | 993.0 | 2.0 |
| 14 | 782.0 | 8.0 | 186.0 | 34.0 |
| 15 | 546.0 | 53.0 | 352.0 | 59.0 |
| 16 | 738.0 | 135.0 | 84.0 | 53.0 |
| 17 | 171.0 | 412.0 | 366.0 | 61.0 |
| 18 | 170.0 | 329.0 | 123.0 | 388.0 |
| 19 | 327.0 | 165.0 | 265.0 | 253.0 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.369 | 0.169 | 0.335 | 0.127 |
| 02 | 0.542 | 0.093 | 0.204 | 0.161 |
| 03 | 0.641 | 0.075 | 0.129 | 0.155 |
| 04 | 0.587 | 0.025 | 0.154 | 0.234 |
| 05 | 0.226 | 0.123 | 0.619 | 0.033 |
| 06 | 0.534 | 0.11 | 0.33 | 0.027 |
| 07 | 0.168 | 0.0 | 0.83 | 0.002 |
| 08 | 0.05 | 0.001 | 0.95 | 0.0 |
| 09 | 0.993 | 0.003 | 0.002 | 0.002 |
| 10 | 0.983 | 0.002 | 0.005 | 0.01 |
| 11 | 0.076 | 0.286 | 0.632 | 0.006 |
| 12 | 0.068 | 0.063 | 0.014 | 0.854 |
| 13 | 0.014 | 0.001 | 0.983 | 0.002 |
| 14 | 0.774 | 0.008 | 0.184 | 0.034 |
| 15 | 0.541 | 0.052 | 0.349 | 0.058 |
| 16 | 0.731 | 0.134 | 0.083 | 0.052 |
| 17 | 0.169 | 0.408 | 0.362 | 0.06 |
| 18 | 0.168 | 0.326 | 0.122 | 0.384 |
| 19 | 0.324 | 0.163 | 0.262 | 0.25 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.388 | -0.387 | 0.29 | -0.673 |
| 02 | 0.769 | -0.977 | -0.202 | -0.434 |
| 03 | 0.937 | -1.185 | -0.657 | -0.471 |
| 04 | 0.85 | -2.252 | -0.477 | -0.067 |
| 05 | -0.101 | -0.704 | 0.902 | -1.991 |
| 06 | 0.755 | -0.813 | 0.275 | -2.18 |
| 07 | -0.392 | -4.99 | 1.195 | -4.222 |
| 08 | -1.592 | -4.534 | 1.329 | -4.99 |
| 09 | 1.374 | -3.984 | -4.222 | -4.222 |
| 10 | 1.364 | -4.222 | -3.632 | -3.076 |
| 11 | -1.172 | 0.134 | 0.923 | -3.493 |
| 12 | -1.279 | -1.353 | -2.783 | 1.224 |
| 13 | -2.783 | -4.534 | 1.364 | -4.222 |
| 14 | 1.126 | -3.263 | -0.303 | -1.962 |
| 15 | 0.768 | -1.536 | 0.33 | -1.432 |
| 16 | 1.068 | -0.62 | -1.087 | -1.536 |
| 17 | -0.387 | 0.487 | 0.369 | -1.399 |
| 18 | -0.392 | 0.263 | -0.712 | 0.427 |
| 19 | 0.257 | -0.422 | 0.048 | 0.002 |
| P-value | Threshold |
|---|---|
| 0.001 | 2.43016 |
| 0.0005 | 3.70361 |
| 0.0001 | 6.34261 |