| Motif | IRF5.H14RSNP.0.SM.B |
| Gene (human) | IRF5 (GeneCards) |
| Gene synonyms (human) | |
| Gene (mouse) | Irf5 |
| Gene synonyms (mouse) | |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 0 |
| Quality | B |
| Motif | IRF5.H14RSNP.0.SM.B |
| Gene (human) | IRF5 (GeneCards) |
| Gene synonyms (human) | |
| Gene (mouse) | Irf5 |
| Gene synonyms (mouse) | |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 0 |
| Quality | B |
| Motif length | 20 |
| Consensus | nhhnvYGAAACCGAAACYdn |
| GC content | 44.88% |
| Information content (bits; total / per base) | 20.414 / 1.021 |
| Data sources | HT-SELEX + Methyl-HT-SELEX |
| Aligned words | 388 |
| Previous names | IRF5.H12RSNP.0.SM.B |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mouse | 4 (26) | 0.713 | 0.756 | 0.585 | 0.642 | 0.747 | 0.791 | 2.247 | 2.574 | 42.146 | 63.469 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 6 experiments | median | 0.993 | 0.99 | 0.962 | 0.953 | 0.861 | 0.861 |
| best | 1.0 | 0.999 | 0.996 | 0.995 | 0.969 | 0.965 | |
| Methyl HT-SELEX, 2 experiments | median | 0.995 | 0.993 | 0.968 | 0.962 | 0.861 | 0.862 |
| best | 0.999 | 0.999 | 0.987 | 0.984 | 0.896 | 0.897 | |
| Non-Methyl HT-SELEX, 4 experiments | median | 0.769 | 0.771 | 0.744 | 0.745 | 0.703 | 0.702 |
| best | 1.0 | 0.999 | 0.996 | 0.995 | 0.969 | 0.965 | |
| rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
|---|---|---|---|---|
| batch 2 | 0.545 | 0.195 | 0.484 | 0.334 |
| TF superclass | Helix-turn-helix domains {3} (TFClass) |
| TF class | Tryptophan cluster factors {3.5} (TFClass) |
| TF family | IRF {3.5.3} (TFClass) |
| TF subfamily | {3.5.3.0} (TFClass) |
| TFClass ID | TFClass: 3.5.3.0.5 |
| HGNC | HGNC:6120 |
| MGI | MGI:1350924 |
| EntrezGene (human) | GeneID:3663 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:27056 (SSTAR profile) |
| UniProt ID (human) | IRF5_HUMAN |
| UniProt ID (mouse) | IRF5_MOUSE |
| UniProt AC (human) | Q13568 (TFClass) |
| UniProt AC (mouse) | P56477 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 0 human, 4 mouse |
| HT-SELEX | 4 |
| Methyl-HT-SELEX | 2 |
| Genomic HT-SELEX | 0 overall: 0 Lysate, 0 IVT, 0 GFPIVT |
| SMiLE-Seq | 0 |
| PBM | 0 |
| PCM | IRF5.H14RSNP.0.SM.B.pcm |
| PWM | IRF5.H14RSNP.0.SM.B.pwm |
| PFM | IRF5.H14RSNP.0.SM.B.pfm |
| Threshold to P-value map | IRF5.H14RSNP.0.SM.B.thr |
| Motif in other formats | |
| JASPAR format | IRF5.H14RSNP.0.SM.B_jaspar_format.txt |
| MEME format | IRF5.H14RSNP.0.SM.B_meme_format.meme |
| Transfac format | IRF5.H14RSNP.0.SM.B_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 75.25 | 58.25 | 117.25 | 137.25 |
| 02 | 161.0 | 49.0 | 48.0 | 130.0 |
| 03 | 148.0 | 128.0 | 41.0 | 71.0 |
| 04 | 225.0 | 63.0 | 63.0 | 37.0 |
| 05 | 59.0 | 186.0 | 109.0 | 34.0 |
| 06 | 20.0 | 253.0 | 12.0 | 103.0 |
| 07 | 18.0 | 8.0 | 346.0 | 16.0 |
| 08 | 361.0 | 10.0 | 9.0 | 8.0 |
| 09 | 326.0 | 5.0 | 8.0 | 49.0 |
| 10 | 383.0 | 2.0 | 2.0 | 1.0 |
| 11 | 0.0 | 350.0 | 38.0 | 0.0 |
| 12 | 6.0 | 310.0 | 1.0 | 71.0 |
| 13 | 2.0 | 0.0 | 386.0 | 0.0 |
| 14 | 388.0 | 0.0 | 0.0 | 0.0 |
| 15 | 354.0 | 0.0 | 3.0 | 31.0 |
| 16 | 387.0 | 1.0 | 0.0 | 0.0 |
| 17 | 0.0 | 361.0 | 26.0 | 1.0 |
| 18 | 12.0 | 151.0 | 10.0 | 215.0 |
| 19 | 152.5 | 55.5 | 118.5 | 61.5 |
| 20 | 144.5 | 84.5 | 69.5 | 89.5 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.194 | 0.15 | 0.302 | 0.354 |
| 02 | 0.415 | 0.126 | 0.124 | 0.335 |
| 03 | 0.381 | 0.33 | 0.106 | 0.183 |
| 04 | 0.58 | 0.162 | 0.162 | 0.095 |
| 05 | 0.152 | 0.479 | 0.281 | 0.088 |
| 06 | 0.052 | 0.652 | 0.031 | 0.265 |
| 07 | 0.046 | 0.021 | 0.892 | 0.041 |
| 08 | 0.93 | 0.026 | 0.023 | 0.021 |
| 09 | 0.84 | 0.013 | 0.021 | 0.126 |
| 10 | 0.987 | 0.005 | 0.005 | 0.003 |
| 11 | 0.0 | 0.902 | 0.098 | 0.0 |
| 12 | 0.015 | 0.799 | 0.003 | 0.183 |
| 13 | 0.005 | 0.0 | 0.995 | 0.0 |
| 14 | 1.0 | 0.0 | 0.0 | 0.0 |
| 15 | 0.912 | 0.0 | 0.008 | 0.08 |
| 16 | 0.997 | 0.003 | 0.0 | 0.0 |
| 17 | 0.0 | 0.93 | 0.067 | 0.003 |
| 18 | 0.031 | 0.389 | 0.026 | 0.554 |
| 19 | 0.393 | 0.143 | 0.305 | 0.159 |
| 20 | 0.372 | 0.218 | 0.179 | 0.231 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | -0.25 | -0.5 | 0.187 | 0.343 |
| 02 | 0.501 | -0.668 | -0.688 | 0.289 |
| 03 | 0.417 | 0.274 | -0.841 | -0.307 |
| 04 | 0.833 | -0.423 | -0.423 | -0.94 |
| 05 | -0.487 | 0.644 | 0.115 | -1.021 |
| 06 | -1.522 | 0.949 | -1.988 | 0.059 |
| 07 | -1.62 | -2.34 | 1.261 | -1.728 |
| 08 | 1.303 | -2.148 | -2.24 | -2.34 |
| 09 | 1.202 | -2.72 | -2.34 | -0.668 |
| 10 | 1.362 | -3.34 | -3.34 | -3.678 |
| 11 | -4.191 | 1.272 | -0.914 | -4.191 |
| 12 | -2.576 | 1.151 | -3.678 | -0.307 |
| 13 | -3.34 | -4.191 | 1.37 | -4.191 |
| 14 | 1.375 | -4.191 | -4.191 | -4.191 |
| 15 | 1.284 | -4.191 | -3.088 | -1.109 |
| 16 | 1.372 | -3.678 | -4.191 | -4.191 |
| 17 | -4.191 | 1.303 | -1.276 | -3.678 |
| 18 | -1.988 | 0.437 | -2.148 | 0.788 |
| 19 | 0.447 | -0.547 | 0.197 | -0.447 |
| 20 | 0.394 | -0.136 | -0.327 | -0.079 |
| P-value | Threshold |
|---|---|
| 0.001 | 0.05016 |
| 0.0005 | 1.52636 |
| 0.0001 | 4.64546 |