MotifIRF3.H14RSNP.1.SM.B
Gene (human)IRF3
(GeneCards)
Gene synonyms (human)
Gene (mouse)Irf3
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype1
Quality
B
Motif length26
ConsensushdCvGTTTCSvSGAAACCGAAAChdn
GC content50.45%
Information content (bits; total / per base)33.873 / 1.303
Data sourcesHT-SELEX + Methyl-HT-SELEX
Aligned words372
Previous namesIRF3.H12RSNP.1.SM.B

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Mouse 7 (46) 0.5 0.503 0.335 0.34 0.524 0.557 1.196 1.262 1.105 3.921

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 5 experiments median 0.627 0.61 0.547 0.561 0.519 0.536
best 0.675 0.669 0.59 0.58 0.539 0.546
Methyl HT-SELEX, 1 experiments median 0.584 0.61 0.532 0.551 0.512 0.527
best 0.584 0.61 0.532 0.551 0.512 0.527
Non-Methyl HT-SELEX, 4 experiments median 0.632 0.619 0.558 0.57 0.526 0.538
best 0.675 0.669 0.59 0.58 0.539 0.546

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 1 0.655 0.072 0.662 0.404
batch 2 0.554 0.199 0.519 0.331
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classTryptophan cluster factors {3.5} (TFClass)
TF familyIRF {3.5.3} (TFClass)
TF subfamily {3.5.3.0} (TFClass)
TFClass IDTFClass: 3.5.3.0.3
HGNCHGNC:6118
MGIMGI:1859179
EntrezGene (human)GeneID:3661
(SSTAR profile)
EntrezGene (mouse)GeneID:54131
(SSTAR profile)
UniProt ID (human)IRF3_HUMAN
UniProt ID (mouse)IRF3_MOUSE
UniProt AC (human)Q14653
(TFClass)
UniProt AC (mouse)P70671
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 0 human, 7 mouse
HT-SELEX 4
Methyl-HT-SELEX 1
Genomic HT-SELEX 0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq 0
PBM 0
PCM
ACGT
01180.562.520.5108.5
0264.537.591.5178.5
0314.0310.026.022.0
04118.0127.0114.013.0
050.05.0365.02.0
061.00.00.0371.0
070.00.00.0372.0
080.01.00.0371.0
090.0372.00.00.0
1012.0138.0221.01.0
1177.0160.0103.032.0
123.0195.0164.010.0
137.00.0365.00.0
14366.00.06.00.0
15372.00.00.00.0
16372.00.00.00.0
170.0371.01.00.0
180.0346.08.018.0
190.00.0372.00.0
20371.01.00.00.0
21359.00.00.013.0
22352.014.06.00.0
232.0292.067.011.0
2470.0198.029.075.0
25172.024.0107.069.0
26101.7580.7578.75110.75
PFM
ACGT
010.4850.1680.0550.292
020.1730.1010.2460.48
030.0380.8330.070.059
040.3170.3410.3060.035
050.00.0130.9810.005
060.0030.00.00.997
070.00.00.01.0
080.00.0030.00.997
090.01.00.00.0
100.0320.3710.5940.003
110.2070.430.2770.086
120.0080.5240.4410.027
130.0190.00.9810.0
140.9840.00.0160.0
151.00.00.00.0
161.00.00.00.0
170.00.9970.0030.0
180.00.930.0220.048
190.00.01.00.0
200.9970.0030.00.0
210.9650.00.00.035
220.9460.0380.0160.0
230.0050.7850.180.03
240.1880.5320.0780.202
250.4620.0650.2880.185
260.2740.2170.2120.298
PWM
ACGT
010.656-0.39-1.4580.152
02-0.359-0.885-0.0160.644
03-1.8091.193-1.235-1.392
040.2350.3070.201-1.876
05-4.157-2.681.356-3.301
06-3.64-4.157-4.1571.372
07-4.157-4.157-4.1571.374
08-4.157-3.64-4.1571.372
09-4.1571.374-4.157-4.157
10-1.9470.390.856-3.64
11-0.1860.5360.101-1.037
12-3.0490.7320.56-2.108
13-2.411-4.1571.356-4.157
141.358-4.157-2.536-4.157
151.374-4.157-4.157-4.157
161.374-4.157-4.157-4.157
17-4.1571.372-3.64-4.157
18-4.1571.302-2.299-1.579
19-4.157-4.1571.374-4.157
201.372-3.64-4.157-4.157
211.339-4.157-4.157-1.876
221.319-1.809-2.536-4.157
23-3.3011.133-0.322-2.024
24-0.2790.747-1.131-0.211
250.608-1.3110.138-0.293
260.089-0.139-0.1630.172
Standard thresholds
P-value Threshold
0.001 -10.82209
0.0005 -8.73439
0.0001 -4.24484