HSF1.H14INVIVO.2.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HSF1.H14INVIVO.2.P.B
Gene (human)	HSF1 (GeneCards)
Gene synonyms (human)	HSTF1
Gene (mouse)	Hsf1
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	2
Quality	B

Motif length	16
Consensus	GGRhTYGARCMMdSRM
GC content	61.43%
Information content (bits; total / per base)	13.102 / 0.819
Data sources	ChIP-Seq
Aligned words	240
Previous names	HSF1.H12INVIVO.2.P.B

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	37 (203)	0.477	0.621	0.312	0.521	0.478	0.665	1.026	3.388	0	35.092
Mouse	11 (62)	0.522	0.84	0.33	0.648	0.493	0.907	1.036	7.227	0.0	54.921

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 8 experiments	median	0.466	0.479	0.476	0.485	0.483	0.489
Overall, 8 experiments	best	0.582	0.554	0.554	0.537	0.529	0.524
Methyl HT-SELEX, 2 experiments	median	0.397	0.443	0.42	0.454	0.44	0.464
Methyl HT-SELEX, 2 experiments	best	0.407	0.447	0.431	0.459	0.449	0.468
Non-Methyl HT-SELEX, 6 experiments	median	0.473	0.484	0.479	0.488	0.486	0.491
Non-Methyl HT-SELEX, 6 experiments	best	0.582	0.554	0.554	0.537	0.529	0.524

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.449	0.01	0.129	0.125
batch 2	0.493	0.078	-0.023	-0.01

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Heat shock factors {3.4} (TFClass)
TF family	HSF {3.4.1} (TFClass)
TF subfamily	{3.4.1.0} (TFClass)
TFClass ID	TFClass: 3.4.1.0.1
HGNC	HGNC:5224
MGI	MGI:96238
EntrezGene (human)	GeneID:3297 (SSTAR profile)
EntrezGene (mouse)	GeneID:15499 (SSTAR profile)
UniProt ID (human)	HSF1_HUMAN
UniProt ID (mouse)	HSF1_MOUSE
UniProt AC (human)	Q00613 (TFClass)
UniProt AC (mouse)	P38532 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	37 human, 11 mouse
HT-SELEX	6
Methyl-HT-SELEX	2
Genomic HT-SELEX	0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq	0
PBM	0

PCM	HSF1.H14INVIVO.2.P.B.pcm
PWM	HSF1.H14INVIVO.2.P.B.pwm
PFM	HSF1.H14INVIVO.2.P.B.pfm
Threshold to P-value map	HSF1.H14INVIVO.2.P.B.thr
Motif in other formats
JASPAR format	HSF1.H14INVIVO.2.P.B_jaspar_format.txt
MEME format	HSF1.H14INVIVO.2.P.B_meme_format.meme
Transfac format	HSF1.H14INVIVO.2.P.B_transfac_format.txt
Homer format	HSF1.H14INVIVO.2.P.B_homer_format_0.001.txt HSF1.H14INVIVO.2.P.B_homer_format_0.0005.txt HSF1.H14INVIVO.2.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	26.0	5.0	197.0	12.0
02	16.0	15.0	205.0	4.0
03	126.0	9.0	77.0	28.0
04	62.0	65.0	28.0	85.0
05	7.0	17.0	17.0	199.0
06	4.0	142.0	46.0	48.0
07	5.0	11.0	214.0	10.0
08	211.0	5.0	15.0	9.0
09	176.0	11.0	38.0	15.0
10	4.0	183.0	52.0	1.0
11	20.0	192.0	9.0	19.0
12	33.0	169.0	19.0	19.0
13	87.0	17.0	106.0	30.0
14	5.0	67.0	161.0	7.0
15	46.0	24.0	170.0	0.0
16	141.0	62.0	11.0	26.0

PFM

	A	C	G	T
01	0.108	0.021	0.821	0.05
02	0.067	0.063	0.854	0.017
03	0.525	0.038	0.321	0.117
04	0.258	0.271	0.117	0.354
05	0.029	0.071	0.071	0.829
06	0.017	0.592	0.192	0.2
07	0.021	0.046	0.892	0.042
08	0.879	0.021	0.063	0.038
09	0.733	0.046	0.158	0.063
10	0.017	0.763	0.217	0.004
11	0.083	0.8	0.038	0.079
12	0.138	0.704	0.079	0.079
13	0.363	0.071	0.442	0.125
14	0.021	0.279	0.671	0.029
15	0.192	0.1	0.708	0.0
16	0.588	0.258	0.046	0.108

PWM

	A	C	G	T
01	-0.807	-2.265	1.173	-1.524
02	-1.262	-1.321	1.213	-2.436
03	0.73	-1.778	0.245	-0.737
04	0.032	0.078	-0.737	0.342
05	-1.992	-1.206	-1.206	1.183
06	-2.436	0.849	-0.259	-0.218
07	-2.265	-1.602	1.255	-1.686
08	1.241	-2.265	-1.321	-1.778
09	1.061	-1.602	-0.444	-1.321
10	-2.436	1.1	-0.14	-3.254
11	-1.055	1.148	-1.778	-1.103
12	-0.58	1.021	-1.103	-1.103
13	0.365	-1.206	0.559	-0.671
14	-2.265	0.108	0.973	-1.992
15	-0.259	-0.883	1.027	-3.802
16	0.842	0.032	-1.602	-0.807

Standard thresholds

P-value	Threshold
0.001	4.09656
0.0005	5.01851
0.0001	6.96596