HSF1.H14CORE.2.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HSF1.H14CORE.2.P.B
Gene (human)	HSF1 (GeneCards)
Gene synonyms (human)	HSTF1
Gene (mouse)	Hsf1
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	2
Quality	B

Motif length	16
Consensus	YSbRGGTTCRAdbCCM
GC content	61.88%
Information content (bits; total / per base)	14.905 / 0.932
Data sources	ChIP-Seq
Aligned words	80
Previous names	HSF1.H12CORE.2.P.B

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	37 (203)	0.492	0.61	0.316	0.525	0.451	0.628	0.918	3.469	0	56.638
Mouse	11 (62)	0.528	0.862	0.333	0.681	0.462	0.929	0.963	8.223	1.459	62.854

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 8 experiments	median	0.585	0.556	0.572	0.543	0.556	0.535
Overall, 8 experiments	best	0.874	0.811	0.83	0.77	0.766	0.718
Methyl HT-SELEX, 2 experiments	median	0.526	0.506	0.536	0.514	0.537	0.517
Methyl HT-SELEX, 2 experiments	best	0.53	0.509	0.54	0.517	0.541	0.519
Non-Methyl HT-SELEX, 6 experiments	median	0.658	0.601	0.625	0.582	0.591	0.563
Non-Methyl HT-SELEX, 6 experiments	best	0.874	0.811	0.83	0.77	0.766	0.718

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.554	0.018	0.342	0.245
batch 2	0.472	0.075	0.042	-0.008

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Heat shock factors {3.4} (TFClass)
TF family	HSF {3.4.1} (TFClass)
TF subfamily	{3.4.1.0} (TFClass)
TFClass ID	TFClass: 3.4.1.0.1
HGNC	HGNC:5224
MGI	MGI:96238
EntrezGene (human)	GeneID:3297 (SSTAR profile)
EntrezGene (mouse)	GeneID:15499 (SSTAR profile)
UniProt ID (human)	HSF1_HUMAN
UniProt ID (mouse)	HSF1_MOUSE
UniProt AC (human)	Q00613 (TFClass)
UniProt AC (mouse)	P38532 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	37 human, 11 mouse
HT-SELEX	6
Methyl-HT-SELEX	2
Genomic HT-SELEX	0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq	0
PBM	0

PCM	HSF1.H14CORE.2.P.B.pcm
PWM	HSF1.H14CORE.2.P.B.pwm
PFM	HSF1.H14CORE.2.P.B.pfm
Threshold to P-value map	HSF1.H14CORE.2.P.B.thr
Motif in other formats
JASPAR format	HSF1.H14CORE.2.P.B_jaspar_format.txt
MEME format	HSF1.H14CORE.2.P.B_meme_format.meme
Transfac format	HSF1.H14CORE.2.P.B_transfac_format.txt
Homer format	HSF1.H14CORE.2.P.B_homer_format_0.001.txt HSF1.H14CORE.2.P.B_homer_format_0.0005.txt HSF1.H14CORE.2.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	9.0	58.0	1.0	12.0
02	5.0	31.0	40.0	4.0
03	10.0	40.0	11.0	19.0
04	15.0	4.0	51.0	10.0
05	10.0	1.0	68.0	1.0
06	2.0	3.0	74.0	1.0
07	6.0	4.0	0.0	70.0
08	3.0	1.0	0.0	76.0
09	2.0	75.0	2.0	1.0
10	9.0	5.0	60.0	6.0
11	74.0	3.0	1.0	2.0
12	25.0	5.0	27.0	23.0
13	9.0	17.0	13.0	41.0
14	12.0	65.0	2.0	1.0
15	3.0	68.0	6.0	3.0
16	17.0	47.0	9.0	7.0

PFM

	A	C	G	T
01	0.113	0.725	0.013	0.15
02	0.063	0.388	0.5	0.05
03	0.125	0.5	0.138	0.238
04	0.188	0.05	0.638	0.125
05	0.125	0.013	0.85	0.013
06	0.025	0.038	0.925	0.013
07	0.075	0.05	0.0	0.875
08	0.038	0.013	0.0	0.95
09	0.025	0.938	0.025	0.013
10	0.113	0.063	0.75	0.075
11	0.925	0.038	0.013	0.025
12	0.313	0.063	0.338	0.288
13	0.113	0.213	0.163	0.513
14	0.15	0.813	0.025	0.013
15	0.038	0.85	0.075	0.038
16	0.213	0.588	0.113	0.088

PWM

	A	C	G	T
01	-0.737	1.03	-2.309	-0.477
02	-1.242	0.42	0.667	-1.421
03	-0.643	0.667	-0.556	-0.049
04	-0.271	-1.421	0.904	-0.643
05	-0.643	-2.309	1.186	-2.309
06	-1.919	-1.639	1.27	-2.309
07	-1.09	-1.421	-2.958	1.215
08	-1.639	-2.309	-2.958	1.296
09	-1.919	1.283	-1.919	-2.309
10	-0.737	-1.242	1.063	-1.09
11	1.27	-1.639	-2.309	-1.919
12	0.213	-1.242	0.287	0.133
13	-0.737	-0.153	-0.403	0.691
14	-0.477	1.142	-1.919	-2.309
15	-1.639	1.186	-1.09	-1.639
16	-0.153	0.824	-0.737	-0.958

Standard thresholds

P-value	Threshold
0.001	3.86661
0.0005	4.83021
0.0001	6.86886