| Motif | HSF1.H14CORE.0.PSM.A |
| Gene (human) | HSF1 (GeneCards) |
| Gene synonyms (human) | HSTF1 |
| Gene (mouse) | Hsf1 |
| Gene synonyms (mouse) | |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 0 |
| Quality | A |
| Motif | HSF1.H14CORE.0.PSM.A |
| Gene (human) | HSF1 (GeneCards) |
| Gene synonyms (human) | HSTF1 |
| Gene (mouse) | Hsf1 |
| Gene synonyms (mouse) | |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 0 |
| Quality | A |
| Motif length | 18 |
| Consensus | nhRGAAbRTTCTAGAAnv |
| GC content | 38.17% |
| Information content (bits; total / per base) | 20.888 / 1.16 |
| Data sources | ChIP-Seq + HT-SELEX + Methyl-HT-SELEX |
| Aligned words | 2367 |
| Previous names | HSF1.H12CORE.0.PSM.A |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Human | 37 (203) | 0.917 | 0.992 | 0.884 | 0.983 | 0.91 | 0.991 | 5.258 | 6.818 | 156.092 | 708.119 |
| Mouse | 11 (62) | 0.936 | 0.981 | 0.912 | 0.959 | 0.94 | 0.982 | 5.9 | 6.813 | 349.188 | 597.658 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 8 experiments | median | 1.0 | 1.0 | 0.998 | 0.998 | 0.952 | 0.955 |
| best | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | |
| Methyl HT-SELEX, 2 experiments | median | 1.0 | 1.0 | 1.0 | 0.999 | 0.994 | 0.993 |
| best | 1.0 | 1.0 | 1.0 | 1.0 | 0.998 | 0.998 | |
| Non-Methyl HT-SELEX, 6 experiments | median | 1.0 | 0.999 | 0.996 | 0.996 | 0.908 | 0.916 |
| best | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | |
| rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
|---|---|---|---|---|
| batch 1 | 0.959 | 0.727 | 0.95 | 0.603 |
| batch 2 | 0.591 | 0.204 | 0.556 | 0.308 |
| TF superclass | Helix-turn-helix domains {3} (TFClass) |
| TF class | Heat shock factors {3.4} (TFClass) |
| TF family | HSF {3.4.1} (TFClass) |
| TF subfamily | {3.4.1.0} (TFClass) |
| TFClass ID | TFClass: 3.4.1.0.1 |
| HGNC | HGNC:5224 |
| MGI | MGI:96238 |
| EntrezGene (human) | GeneID:3297 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:15499 (SSTAR profile) |
| UniProt ID (human) | HSF1_HUMAN |
| UniProt ID (mouse) | HSF1_MOUSE |
| UniProt AC (human) | Q00613 (TFClass) |
| UniProt AC (mouse) | P38532 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 37 human, 11 mouse |
| HT-SELEX | 6 |
| Methyl-HT-SELEX | 2 |
| Genomic HT-SELEX | 0 overall: 0 Lysate, 0 IVT, 0 GFPIVT |
| SMiLE-Seq | 0 |
| PBM | 0 |
| PCM | HSF1.H14CORE.0.PSM.A.pcm |
| PWM | HSF1.H14CORE.0.PSM.A.pwm |
| PFM | HSF1.H14CORE.0.PSM.A.pfm |
| Threshold to P-value map | HSF1.H14CORE.0.PSM.A.thr |
| Motif in other formats | |
| JASPAR format | HSF1.H14CORE.0.PSM.A_jaspar_format.txt |
| MEME format | HSF1.H14CORE.0.PSM.A_meme_format.meme |
| Transfac format | HSF1.H14CORE.0.PSM.A_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 828.25 | 581.25 | 553.25 | 404.25 |
| 02 | 388.25 | 600.25 | 331.25 | 1047.25 |
| 03 | 1223.0 | 433.0 | 682.0 | 29.0 |
| 04 | 9.0 | 8.0 | 2339.0 | 11.0 |
| 05 | 2336.0 | 11.0 | 11.0 | 9.0 |
| 06 | 2317.0 | 8.0 | 17.0 | 25.0 |
| 07 | 188.0 | 1046.0 | 229.0 | 904.0 |
| 08 | 892.0 | 169.0 | 1218.0 | 88.0 |
| 09 | 17.0 | 4.0 | 1.0 | 2345.0 |
| 10 | 2.0 | 1.0 | 9.0 | 2355.0 |
| 11 | 2.0 | 2365.0 | 0.0 | 0.0 |
| 12 | 1.0 | 224.0 | 236.0 | 1906.0 |
| 13 | 2032.0 | 137.0 | 198.0 | 0.0 |
| 14 | 1.0 | 1.0 | 2363.0 | 2.0 |
| 15 | 2318.0 | 24.0 | 10.0 | 15.0 |
| 16 | 2250.0 | 22.0 | 30.0 | 65.0 |
| 17 | 572.75 | 717.75 | 552.75 | 523.75 |
| 18 | 878.0 | 406.0 | 723.0 | 360.0 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.35 | 0.246 | 0.234 | 0.171 |
| 02 | 0.164 | 0.254 | 0.14 | 0.442 |
| 03 | 0.517 | 0.183 | 0.288 | 0.012 |
| 04 | 0.004 | 0.003 | 0.988 | 0.005 |
| 05 | 0.987 | 0.005 | 0.005 | 0.004 |
| 06 | 0.979 | 0.003 | 0.007 | 0.011 |
| 07 | 0.079 | 0.442 | 0.097 | 0.382 |
| 08 | 0.377 | 0.071 | 0.515 | 0.037 |
| 09 | 0.007 | 0.002 | 0.0 | 0.991 |
| 10 | 0.001 | 0.0 | 0.004 | 0.995 |
| 11 | 0.001 | 0.999 | 0.0 | 0.0 |
| 12 | 0.0 | 0.095 | 0.1 | 0.805 |
| 13 | 0.858 | 0.058 | 0.084 | 0.0 |
| 14 | 0.0 | 0.0 | 0.998 | 0.001 |
| 15 | 0.979 | 0.01 | 0.004 | 0.006 |
| 16 | 0.951 | 0.009 | 0.013 | 0.027 |
| 17 | 0.242 | 0.303 | 0.234 | 0.221 |
| 18 | 0.371 | 0.172 | 0.305 | 0.152 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.335 | -0.018 | -0.067 | -0.38 |
| 02 | -0.42 | 0.014 | -0.578 | 0.569 |
| 03 | 0.724 | -0.311 | 0.142 | -2.954 |
| 04 | -3.994 | -4.09 | 1.372 | -3.826 |
| 05 | 1.371 | -3.826 | -3.826 | -3.994 |
| 06 | 1.363 | -4.09 | -3.445 | -3.093 |
| 07 | -1.14 | 0.568 | -0.944 | 0.423 |
| 08 | 0.409 | -1.245 | 0.72 | -1.887 |
| 09 | -3.445 | -4.604 | -5.307 | 1.375 |
| 10 | -5.015 | -5.307 | -3.994 | 1.379 |
| 11 | -5.015 | 1.383 | -5.722 | -5.722 |
| 12 | -5.307 | -0.966 | -0.914 | 1.167 |
| 13 | 1.231 | -1.452 | -1.088 | -5.722 |
| 14 | -5.307 | -5.307 | 1.382 | -5.015 |
| 15 | 1.363 | -3.13 | -3.906 | -3.557 |
| 16 | 1.333 | -3.211 | -2.922 | -2.183 |
| 17 | -0.033 | 0.192 | -0.068 | -0.122 |
| 18 | 0.393 | -0.375 | 0.2 | -0.495 |
| P-value | Threshold |
|---|---|
| 0.001 | -2.43159 |
| 0.0005 | -0.66824 |
| 0.0001 | 3.06226 |