MotifFOXA2.H14CORE.0.PSM.A
Gene (human)FOXA2
(GeneCards)
Gene synonyms (human)HNF3B, TCF3B
Gene (mouse)Foxa2
Gene synonyms (mouse)Hnf3b, Tcf-3b, Tcf3b
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length12
ConsensusTGTTTACWbWdn
GC content33.1%
Information content (bits; total / per base)13.023 / 1.085
Data sourcesChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words1000
Previous namesFOXA2.H12CORE.0.PSM.A

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 54 (310) 0.918 0.973 0.85 0.954 0.923 0.974 3.664 5.074 263.436 623.268
Mouse 20 (114) 0.9 0.961 0.838 0.921 0.904 0.963 3.634 4.418 280.404 573.398

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 2 experiments median 0.981 0.966 0.967 0.949 0.926 0.904
best 0.988 0.979 0.977 0.964 0.93 0.915
Methyl HT-SELEX, 1 experiments median 0.988 0.979 0.977 0.964 0.93 0.915
best 0.988 0.979 0.977 0.964 0.93 0.915
Non-Methyl HT-SELEX, 1 experiments median 0.973 0.953 0.958 0.934 0.921 0.893
best 0.973 0.953 0.958 0.934 0.921 0.893

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 13.819 47.484 0.325 0.284

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 1 0.965 0.785 0.923 0.472
batch 2 0.679 0.097 0.675 0.476
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classFork head/winged helix factors {3.3} (TFClass)
TF familyFOX {3.3.1} (TFClass)
TF subfamilyFOXA {3.3.1.1} (TFClass)
TFClass IDTFClass: 3.3.1.1.2
HGNCHGNC:5022
MGIMGI:1347476
EntrezGene (human)GeneID:3170
(SSTAR profile)
EntrezGene (mouse)GeneID:15376
(SSTAR profile)
UniProt ID (human)FOXA2_HUMAN
UniProt ID (mouse)FOXA2_MOUSE
UniProt AC (human)Q9Y261
(TFClass)
UniProt AC (mouse)P35583
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 54 human, 20 mouse
HT-SELEX 1
Methyl-HT-SELEX 1
Genomic HT-SELEX 0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq 0
PBM 0
PCM
ACGT
018.04.01.0987.0
02265.01.0734.00.0
030.01.01.0998.0
040.00.063.0937.0
052.00.0215.0783.0
06823.01.0175.01.0
077.0947.00.046.0
08442.0115.02.0441.0
0961.0378.087.0474.0
10601.06.022.0371.0
11229.0112.0482.0177.0
12129.0280.0345.0246.0
PFM
ACGT
010.0080.0040.0010.987
020.2650.0010.7340.0
030.00.0010.0010.998
040.00.00.0630.937
050.0020.00.2150.783
060.8230.0010.1750.001
070.0070.9470.00.046
080.4420.1150.0020.441
090.0610.3780.0870.474
100.6010.0060.0220.371
110.2290.1120.4820.177
120.1290.280.3450.246
PWM
ACGT
01-3.253-3.783-4.5251.368
020.058-4.5251.073-4.982
03-4.982-4.525-4.5251.379
04-4.982-4.982-1.3581.316
05-4.213-4.982-0.151.137
061.187-4.525-0.354-4.525
07-3.3621.327-4.982-1.663
080.567-0.769-4.2130.565
09-1.390.411-1.0430.636
100.873-3.484-2.3620.393
11-0.087-0.7950.653-0.342
12-0.6550.1130.32-0.016
Standard thresholds
P-value Threshold
0.001 3.312975
0.0005 4.533515
0.0001 7.280665