| Motif | FOXA1.H14RSNP.0.P.B |
| Gene (human) | FOXA1 (GeneCards) |
| Gene synonyms (human) | HNF3A, TCF3A |
| Gene (mouse) | Foxa1 |
| Gene synonyms (mouse) | Hnf3a, Tcf-3a, Tcf3a |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 0 |
| Quality | B |
| Motif | FOXA1.H14RSNP.0.P.B |
| Gene (human) | FOXA1 (GeneCards) |
| Gene synonyms (human) | HNF3A, TCF3A |
| Gene (mouse) | Foxa1 |
| Gene synonyms (mouse) | Hnf3a, Tcf-3a, Tcf3a |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 0 |
| Quality | B |
| Motif length | 11 |
| Consensus | TGTTTACWbdv |
| GC content | 31.27% |
| Information content (bits; total / per base) | 10.072 / 0.916 |
| Data sources | ChIP-Seq |
| Aligned words | 1004 |
| Previous names | FOXA1.H12RSNP.0.P.B |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Human | 203 (408) | 0.93 | 0.969 | 0.854 | 0.932 | 0.935 | 0.964 | 3.651 | 4.327 | 276.431 | 728.086 |
| Mouse | 32 (69) | 0.93 | 0.946 | 0.857 | 0.887 | 0.936 | 0.949 | 3.754 | 4.028 | 474.081 | 723.137 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 4 experiments | median | 0.933 | 0.908 | 0.811 | 0.799 | 0.677 | 0.691 |
| best | 0.986 | 0.983 | 0.954 | 0.934 | 0.859 | 0.847 | |
| Methyl HT-SELEX, 2 experiments | median | 0.879 | 0.843 | 0.768 | 0.742 | 0.662 | 0.66 |
| best | 0.886 | 0.851 | 0.791 | 0.759 | 0.686 | 0.677 | |
| Non-Methyl HT-SELEX, 2 experiments | median | 0.982 | 0.974 | 0.892 | 0.887 | 0.763 | 0.776 |
| best | 0.986 | 0.983 | 0.954 | 0.934 | 0.859 | 0.847 | |
| rSNP benchmarking, ADASTRA | odds-ratio | -log-Fisher's P | Pearson r | Kendall tau |
|---|---|---|---|---|
| # | 8.24 | 158.291 | 0.333 | 0.321 |
| rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
|---|---|---|---|---|
| batch 1 | 0.917 | 0.259 | 0.893 | 0.668 |
| batch 2 | 0.792 | 0.481 | 0.67 | 0.496 |
| TF superclass | Helix-turn-helix domains {3} (TFClass) |
| TF class | Fork head/winged helix factors {3.3} (TFClass) |
| TF family | FOX {3.3.1} (TFClass) |
| TF subfamily | FOXA {3.3.1.1} (TFClass) |
| TFClass ID | TFClass: 3.3.1.1.1 |
| HGNC | HGNC:5021 |
| MGI | MGI:1347472 |
| EntrezGene (human) | GeneID:3169 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:15375 (SSTAR profile) |
| UniProt ID (human) | FOXA1_HUMAN |
| UniProt ID (mouse) | FOXA1_MOUSE |
| UniProt AC (human) | P55317 (TFClass) |
| UniProt AC (mouse) | P35582 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 203 human, 32 mouse |
| HT-SELEX | 2 |
| Methyl-HT-SELEX | 2 |
| Genomic HT-SELEX | 0 overall: 0 Lysate, 0 IVT, 0 GFPIVT |
| SMiLE-Seq | 0 |
| PBM | 0 |
| PCM | FOXA1.H14RSNP.0.P.B.pcm |
| PWM | FOXA1.H14RSNP.0.P.B.pwm |
| PFM | FOXA1.H14RSNP.0.P.B.pfm |
| Threshold to P-value map | FOXA1.H14RSNP.0.P.B.thr |
| Motif in other formats | |
| JASPAR format | FOXA1.H14RSNP.0.P.B_jaspar_format.txt |
| MEME format | FOXA1.H14RSNP.0.P.B_meme_format.meme |
| Transfac format | FOXA1.H14RSNP.0.P.B_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 32.0 | 17.0 | 23.0 | 932.0 |
| 02 | 272.0 | 10.0 | 716.0 | 6.0 |
| 03 | 9.0 | 20.0 | 25.0 | 950.0 |
| 04 | 11.0 | 4.0 | 99.0 | 890.0 |
| 05 | 6.0 | 3.0 | 178.0 | 817.0 |
| 06 | 773.0 | 10.0 | 193.0 | 28.0 |
| 07 | 30.0 | 805.0 | 13.0 | 156.0 |
| 08 | 414.0 | 150.0 | 23.0 | 417.0 |
| 09 | 108.0 | 273.0 | 166.0 | 457.0 |
| 10 | 477.0 | 65.0 | 81.0 | 381.0 |
| 11 | 250.0 | 180.0 | 400.0 | 174.0 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.032 | 0.017 | 0.023 | 0.928 |
| 02 | 0.271 | 0.01 | 0.713 | 0.006 |
| 03 | 0.009 | 0.02 | 0.025 | 0.946 |
| 04 | 0.011 | 0.004 | 0.099 | 0.886 |
| 05 | 0.006 | 0.003 | 0.177 | 0.814 |
| 06 | 0.77 | 0.01 | 0.192 | 0.028 |
| 07 | 0.03 | 0.802 | 0.013 | 0.155 |
| 08 | 0.412 | 0.149 | 0.023 | 0.415 |
| 09 | 0.108 | 0.272 | 0.165 | 0.455 |
| 10 | 0.475 | 0.065 | 0.081 | 0.379 |
| 11 | 0.249 | 0.179 | 0.398 | 0.173 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | -2.014 | -2.602 | -2.324 | 1.307 |
| 02 | 0.08 | -3.07 | 1.044 | -3.487 |
| 03 | -3.159 | -2.454 | -2.247 | 1.326 |
| 04 | -2.989 | -3.787 | -0.92 | 1.261 |
| 05 | -3.487 | -3.979 | -0.341 | 1.175 |
| 06 | 1.12 | -3.07 | -0.261 | -2.14 |
| 07 | -2.075 | 1.161 | -2.843 | -0.471 |
| 08 | 0.498 | -0.51 | -2.324 | 0.505 |
| 09 | -0.834 | 0.083 | -0.41 | 0.596 |
| 10 | 0.639 | -1.332 | -1.117 | 0.415 |
| 11 | -0.004 | -0.33 | 0.463 | -0.363 |
| P-value | Threshold |
|---|---|
| 0.001 | 4.71108 |
| 0.0005 | 5.581055 |
| 0.0001 | 7.38965 |