ETV2.H14INVIVO.1.PM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ETV2.H14INVIVO.1.PM.A
Gene (human)	ETV2 (GeneCards)
Gene synonyms (human)	ER71, ETSRP71
Gene (mouse)	Etv2
Gene synonyms (mouse)	Er71, Etsrp71
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	A

Motif length	15
Consensus	vvRSAGGAARbvvvn
GC content	53.81%
Information content (bits; total / per base)	11.212 / 0.747
Data sources	ChIP-Seq + Methyl-HT-SELEX
Aligned words	981
Previous names	ETV2.H12INVIVO.1.PM.A

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (6)	0.949	0.952	0.888	0.896	0.947	0.949	3.985	4.045	221.53	255.119
Mouse	2 (13)	0.96	0.977	0.905	0.942	0.968	0.976	4.838	5.016	284.155	319.569

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 3 experiments	median	0.975	0.957	0.961	0.938	0.905	0.883
Overall, 3 experiments	best	0.995	0.991	0.99	0.984	0.968	0.958
Methyl HT-SELEX, 1 experiments	median	0.995	0.991	0.99	0.984	0.968	0.958
Methyl HT-SELEX, 1 experiments	best	0.995	0.991	0.99	0.984	0.968	0.958
Non-Methyl HT-SELEX, 2 experiments	median	0.757	0.745	0.739	0.728	0.706	0.696
Non-Methyl HT-SELEX, 2 experiments	best	0.975	0.957	0.961	0.938	0.905	0.883

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.879	0.448	0.842	0.549
batch 2	0.759	0.465	0.751	0.55

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	Ets-related {3.5.2} (TFClass)
TF subfamily	ETS-like {3.5.2.1} (TFClass)
TFClass ID	TFClass: 3.5.2.1.4
HGNC	HGNC:3491
MGI	MGI:99253
EntrezGene (human)	GeneID:2116 (SSTAR profile)
EntrezGene (mouse)	GeneID:14008 (SSTAR profile)
UniProt ID (human)	ETV2_HUMAN
UniProt ID (mouse)	ETV2_MOUSE
UniProt AC (human)	O00321 (TFClass)
UniProt AC (mouse)	P41163 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 2 mouse
HT-SELEX	2
Methyl-HT-SELEX	1
Genomic HT-SELEX	0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq	0
PBM	0

PCM	ETV2.H14INVIVO.1.PM.A.pcm
PWM	ETV2.H14INVIVO.1.PM.A.pwm
PFM	ETV2.H14INVIVO.1.PM.A.pfm
Threshold to P-value map	ETV2.H14INVIVO.1.PM.A.thr
Motif in other formats
JASPAR format	ETV2.H14INVIVO.1.PM.A_jaspar_format.txt
MEME format	ETV2.H14INVIVO.1.PM.A_meme_format.meme
Transfac format	ETV2.H14INVIVO.1.PM.A_transfac_format.txt
Homer format	ETV2.H14INVIVO.1.PM.A_homer_format_0.001.txt ETV2.H14INVIVO.1.PM.A_homer_format_0.0005.txt ETV2.H14INVIVO.1.PM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	447.0	163.0	235.0	136.0
02	359.0	159.0	375.0	88.0
03	517.0	61.0	342.0	61.0
04	89.0	719.0	162.0	11.0
05	772.0	179.0	16.0	14.0
06	7.0	7.0	962.0	5.0
07	5.0	19.0	954.0	3.0
08	941.0	16.0	21.0	3.0
09	866.0	12.0	18.0	85.0
10	435.0	31.0	509.0	6.0
11	79.0	299.0	110.0	493.0
12	307.0	134.0	412.0	128.0
13	136.0	240.0	502.0	103.0
14	181.0	310.0	386.0	104.0
15	236.0	271.0	294.0	180.0

PFM

	A	C	G	T
01	0.456	0.166	0.24	0.139
02	0.366	0.162	0.382	0.09
03	0.527	0.062	0.349	0.062
04	0.091	0.733	0.165	0.011
05	0.787	0.182	0.016	0.014
06	0.007	0.007	0.981	0.005
07	0.005	0.019	0.972	0.003
08	0.959	0.016	0.021	0.003
09	0.883	0.012	0.018	0.087
10	0.443	0.032	0.519	0.006
11	0.081	0.305	0.112	0.503
12	0.313	0.137	0.42	0.13
13	0.139	0.245	0.512	0.105
14	0.185	0.316	0.393	0.106
15	0.241	0.276	0.3	0.183

PWM

	A	C	G	T
01	0.597	-0.405	-0.042	-0.584
02	0.379	-0.43	0.422	-1.013
03	0.742	-1.371	0.331	-1.371
04	-1.001	1.071	-0.411	-2.966
05	1.142	-0.312	-2.634	-2.754
06	-3.343	-3.343	1.362	-3.604
07	-3.604	-2.478	1.353	-3.957
08	1.339	-2.634	-2.386	-3.957
09	1.257	-2.89	-2.528	-1.047
10	0.57	-2.021	0.727	-3.465
11	-1.118	0.197	-0.793	0.695
12	0.223	-0.599	0.516	-0.644
13	-0.584	-0.021	0.713	-0.858
14	-0.301	0.233	0.451	-0.848
15	-0.038	0.099	0.18	-0.307

Standard thresholds

P-value	Threshold
0.001	4.40046
0.0005	5.36566
0.0001	7.33941