ESX1.H14INVIVO.0.SM.D motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ESX1.H14INVIVO.0.SM.D
Gene (human)	ESX1 (GeneCards)
Gene synonyms (human)	ESX1L, ESX1R
Gene (mouse)
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	D

Motif length	11
Consensus	nnYRATTAvbn
GC content	36.35%
Information content (bits; total / per base)	9.768 / 0.888
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	9416
Previous names	ESX1.H12INVIVO.0.SM.D

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.975	0.958	0.965	0.943	0.939	0.916
Overall, 10 experiments	best	0.993	0.988	0.988	0.981	0.976	0.965
Methyl HT-SELEX, 3 experiments	median	0.977	0.961	0.965	0.944	0.943	0.917
Methyl HT-SELEX, 3 experiments	best	0.988	0.979	0.983	0.971	0.972	0.957
Non-Methyl HT-SELEX, 7 experiments	median	0.974	0.956	0.964	0.942	0.937	0.914
Non-Methyl HT-SELEX, 7 experiments	best	0.993	0.988	0.988	0.981	0.976	0.965

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.994	0.772	0.965	0.598
batch 2	0.714	0.484	0.757	0.545

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	Paired-related HD {3.1.3} (TFClass)
TF subfamily	ESX {3.1.3.8} (TFClass)
TFClass ID	TFClass: 3.1.3.8.1
HGNC	HGNC:14865
MGI
EntrezGene (human)	GeneID:80712 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	ESX1_HUMAN
UniProt ID (mouse)
UniProt AC (human)	Q8N693 (TFClass)
UniProt AC (mouse)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	7
Methyl-HT-SELEX	3
Genomic HT-SELEX	0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq	0
PBM	0

PCM	ESX1.H14INVIVO.0.SM.D.pcm
PWM	ESX1.H14INVIVO.0.SM.D.pwm
PFM	ESX1.H14INVIVO.0.SM.D.pfm
Threshold to P-value map	ESX1.H14INVIVO.0.SM.D.thr
Motif in other formats
JASPAR format	ESX1.H14INVIVO.0.SM.D_jaspar_format.txt
MEME format	ESX1.H14INVIVO.0.SM.D_meme_format.meme
Transfac format	ESX1.H14INVIVO.0.SM.D_transfac_format.txt
Homer format	ESX1.H14INVIVO.0.SM.D_homer_format_0.001.txt ESX1.H14INVIVO.0.SM.D_homer_format_0.0005.txt ESX1.H14INVIVO.0.SM.D_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2579.5	2688.5	2437.5	1710.5
02	1661.0	2624.0	3251.0	1880.0
03	287.0	3540.0	286.0	5303.0
04	5650.0	1203.0	2462.0	101.0
05	9283.0	102.0	30.0	1.0
06	0.0	0.0	0.0	9416.0
07	0.0	22.0	0.0	9394.0
08	9395.0	0.0	21.0	0.0
09	2181.0	2254.0	4434.0	547.0
10	465.25	4242.25	2719.25	1989.25
11	1890.75	2345.75	2990.75	2188.75

PFM

	A	C	G	T
01	0.274	0.286	0.259	0.182
02	0.176	0.279	0.345	0.2
03	0.03	0.376	0.03	0.563
04	0.6	0.128	0.261	0.011
05	0.986	0.011	0.003	0.0
06	0.0	0.0	0.0	1.0
07	0.0	0.002	0.0	0.998
08	0.998	0.0	0.002	0.0
09	0.232	0.239	0.471	0.058
10	0.049	0.451	0.289	0.211
11	0.201	0.249	0.318	0.232

PWM

	A	C	G	T
01	0.091	0.133	0.035	-0.319
02	-0.348	0.108	0.323	-0.225
03	-2.097	0.408	-2.101	0.812
04	0.875	-0.67	0.045	-3.127
05	1.371	-3.118	-4.29	-6.575
06	-6.937	-6.937	-6.937	1.386
07	-6.937	-4.575	-6.937	1.383
08	1.383	-6.937	-4.617	-6.937
09	-0.076	-0.043	0.633	-1.456
10	-1.617	0.589	0.144	-0.168
11	-0.219	-0.004	0.239	-0.073

Standard thresholds

P-value	Threshold
0.001	5.19324
0.0005	6.279515
0.0001	7.58244