ESR1.H14INVIVO.1.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ESR1.H14INVIVO.1.P.B
Gene (human)	ESR1 (GeneCards)
Gene synonyms (human)	ESR, NR3A1
Gene (mouse)	Esr1
Gene synonyms (mouse)	Esr, Estr, Estra, Nr3a1
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	9
Consensus	vTGACCYdv
GC content	56.96%
Information content (bits; total / per base)	9.603 / 1.067
Data sources	ChIP-Seq
Aligned words	428
Previous names	ESR1.H12INVIVO.1.P.B

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	269 (425)	0.837	0.912	0.725	0.858	0.798	0.878	2.329	2.749	163.959	424.208
Mouse	22 (29)	0.869	0.896	0.746	0.818	0.831	0.868	2.428	2.737	216.481	403.921

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 1 experiments	median	0.734	0.672	0.655	0.621	0.59	0.58
Non-Methyl HT-SELEX, 1 experiments	best	0.734	0.672	0.655	0.621	0.59	0.58

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	1.825	9.804	0.082	0.092

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	Nuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF family	Steroid hormone receptors {2.1.1} (TFClass)
TF subfamily	ER-like (NR3A) {2.1.1.2} (TFClass)
TFClass ID	TFClass: 2.1.1.2.1
HGNC	HGNC:3467
MGI	MGI:1352467
EntrezGene (human)	GeneID:2099 (SSTAR profile)
EntrezGene (mouse)	GeneID:13982 (SSTAR profile)
UniProt ID (human)	ESR1_HUMAN
UniProt ID (mouse)	ESR1_MOUSE
UniProt AC (human)	P03372 (TFClass)
UniProt AC (mouse)	P19785 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	269 human, 22 mouse
HT-SELEX	1
Methyl-HT-SELEX	0
Genomic HT-SELEX	0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq	0
PBM	0

PCM	ESR1.H14INVIVO.1.P.B.pcm
PWM	ESR1.H14INVIVO.1.P.B.pwm
PFM	ESR1.H14INVIVO.1.P.B.pfm
Threshold to P-value map	ESR1.H14INVIVO.1.P.B.thr
Motif in other formats
JASPAR format	ESR1.H14INVIVO.1.P.B_jaspar_format.txt
MEME format	ESR1.H14INVIVO.1.P.B_meme_format.meme
Transfac format	ESR1.H14INVIVO.1.P.B_transfac_format.txt
Homer format	ESR1.H14INVIVO.1.P.B_homer_format_0.001.txt ESR1.H14INVIVO.1.P.B_homer_format_0.0005.txt ESR1.H14INVIVO.1.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	85.0	126.0	186.0	31.0
02	7.0	4.0	3.0	414.0
03	3.0	3.0	416.0	6.0
04	380.0	35.0	7.0	6.0
05	1.0	420.0	2.0	5.0
06	51.0	372.0	0.0	5.0
07	7.0	120.0	3.0	298.0
08	125.0	46.0	179.0	78.0
09	93.0	83.0	189.0	63.0

PFM

	A	C	G	T
01	0.199	0.294	0.435	0.072
02	0.016	0.009	0.007	0.967
03	0.007	0.007	0.972	0.014
04	0.888	0.082	0.016	0.014
05	0.002	0.981	0.005	0.012
06	0.119	0.869	0.0	0.012
07	0.016	0.28	0.007	0.696
08	0.292	0.107	0.418	0.182
09	0.217	0.194	0.442	0.147

PWM

	A	C	G	T
01	-0.227	0.161	0.547	-1.205
02	-2.545	-2.979	-3.18	1.343
03	-3.18	-3.18	1.347	-2.67
04	1.257	-1.089	-2.545	-2.67
05	-3.765	1.357	-3.43	-2.813
06	-0.726	1.236	-4.272	-2.813
07	-2.545	0.113	-3.18	1.015
08	0.153	-0.826	0.509	-0.311
09	-0.138	-0.25	0.563	-0.52

Standard thresholds

P-value	Threshold
0.001	4.75146
0.0005	5.82232
0.0001	7.57739