MotifASCL1.H14RSNP.0.PSM.A
Gene (human)ASCL1
(GeneCards)
Gene synonyms (human)ASH1, BHLHA46, HASH1
Gene (mouse)Ascl1
Gene synonyms (mouse)Ash1, Mash-1, Mash1
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length17
ConsensusnnRRCAGCTGCbdhnnn
GC content55.6%
Information content (bits; total / per base)15.495 / 0.911
Data sourcesChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words359
Previous namesASCL1.H12RSNP.0.PSM.A

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 14 (78) 0.761 0.905 0.691 0.846 0.731 0.886 2.155 3.041 177.358 290.658
Mouse 11 (68) 0.881 0.952 0.821 0.915 0.83 0.928 2.672 3.402 223.731 411.097

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 2 experiments median 0.936 0.919 0.813 0.801 0.683 0.695
best 0.956 0.938 0.858 0.838 0.722 0.727
Methyl HT-SELEX, 1 experiments median 0.916 0.899 0.769 0.765 0.644 0.663
best 0.916 0.899 0.769 0.765 0.644 0.663
Non-Methyl HT-SELEX, 1 experiments median 0.956 0.938 0.858 0.838 0.722 0.727
best 0.956 0.938 0.858 0.838 0.722 0.727

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 23.6 4.905 0.338 0.22

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 2 0.521 0.062 0.355 0.123
TF superclassBasic domains {1} (TFClass)
TF classBasic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF familyMyoD-ASC-related {1.2.2} (TFClass)
TF subfamilyASC {1.2.2.2} (TFClass)
TFClass IDTFClass: 1.2.2.2.1
HGNCHGNC:738
MGIMGI:96919
EntrezGene (human)GeneID:429
(SSTAR profile)
EntrezGene (mouse)GeneID:17172
(SSTAR profile)
UniProt ID (human)ASCL1_HUMAN
UniProt ID (mouse)ASCL1_MOUSE
UniProt AC (human)P50553
(TFClass)
UniProt AC (mouse)Q02067
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 14 human, 11 mouse
HT-SELEX 1
Methyl-HT-SELEX 1
Genomic HT-SELEX 0 overall: 0 Lysate, 0 IVT, 0 GFPIVT
SMiLE-Seq 0
PBM 0
PCM
ACGT
0183.2586.25118.2571.25
0265.064.0138.092.0
03220.05.077.057.0
04180.021.0158.00.0
050.0359.00.00.0
06359.00.00.00.0
070.00.0359.00.0
080.0359.00.00.0
090.00.00.0359.0
100.00.0359.00.0
111.0297.00.061.0
1217.0128.056.0158.0
1390.038.097.0134.0
1464.0110.033.0152.0
1578.0118.057.0106.0
1669.25106.2562.25121.25
1786.0112.075.086.0
PFM
ACGT
010.2320.240.3290.198
020.1810.1780.3840.256
030.6130.0140.2140.159
040.5010.0580.440.0
050.01.00.00.0
061.00.00.00.0
070.00.01.00.0
080.01.00.00.0
090.00.00.01.0
100.00.01.00.0
110.0030.8270.00.17
120.0470.3570.1560.44
130.2510.1060.270.373
140.1780.3060.0920.423
150.2170.3290.1590.295
160.1930.2960.1730.338
170.240.3120.2090.24
PWM
ACGT
01-0.074-0.0390.272-0.227
02-0.317-0.3320.4250.024
030.887-2.646-0.151-0.445
040.688-1.4010.559-4.127
05-4.1271.374-4.127-4.127
061.374-4.127-4.127-4.127
07-4.127-4.1271.374-4.127
08-4.1271.374-4.127-4.127
09-4.127-4.127-4.1271.374
10-4.127-4.1271.374-4.127
11-3.6091.185-4.127-0.379
12-1.5970.35-0.4620.559
130.003-0.8380.0760.395
14-0.3320.2-0.9730.52
15-0.1380.27-0.4450.164
16-0.2550.166-0.3590.297
17-0.0420.218-0.176-0.042
Standard thresholds
P-value Threshold
0.001 2.00371
0.0005 3.59991
0.0001 6.04346