HOmo sapiens COmprehensive MOdel COllection (HOCOMOCO) v14 provides 1595 transcription factor (TF) binding models including secondary motif subtypes for 1107 human TFs and 809 mouse orthologs.

The HOCOMOCO motif models are derived from ChIP-Seq, HT-SELEX, GHT-SELEX, SMiLE-Seq and PBM data by DNA motif discovery with ChIPMunk. The resulting motifs were manually curated and rigorously benchmarked. The preprocessed ChIP-Seq data was extracted from the GTRD database of the BioUML platform. The motifs added in v14 are derived from Codebook MEX.

MoLoTool provides an interactive web GUI for sequence scanning to identify HOCOMOCO motif occurrences in a given set of DNA sequences.